Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE A ligand-based and enediyne-energized bispecific fusion protein targeting epidermal growth factor receptor and insulin-like growth factor-1 receptor shows potent antitumor efficacy against esophageal cancer. 28498434 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE Up-Regulation of MicroRNA-133a Inhibits the MEK/ERK Signaling Pathway to Promote Cell Apoptosis and Enhance Radio-Sensitivity by Targeting EGFR in Esophageal Cancer In Vivo and In Vitro. 27933650 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE Gefitinib and EGFR Gene Copy Number Aberrations in Esophageal Cancer. 28537764 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer. 25739674 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE Real-time quantitative polymerase chain reaction technology (RT-PCR) was used to detect the expression of VEGF, HER-2, and EGFR mRNA in esophageal squamous cancer tissue of 60 cases and 30 cases of VEGF, HER-2, and EGFR mRNA in esophageal cancer adjacent tissues, and analyze its relationship with clinicopathological features. 26099724 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE EGFR intron-1 CA repeat polymorphism is a predictor of relapse and survival in complete resected only surgically treated esophageal cancer. 23377570 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE Over-expression of epidermal growth factor receptor in esophageal cancer is associated with poor prognosis. 22555809 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE A panel of gastric and esophageal cancer cell lines was treated with wortmannin as an Akt-signal inhibitor; the MAPK signal inhibitor PD98059; lapatinib, which inhibits both the epidermal growth factor receptor and HER2 tyrosine kinase; or siRNA for MAPK. 24244023 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 PosttranslationalModification disease BEFREE Microtubule inhibition causes epidermal growth factor receptor inactivation in oesophageal cancer cells. 23174948 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease CTD_human MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib. 22042947 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE Pingyangmycin downregulates the expression of EGFR and enhances the effects of cetuximab on esophageal cancer cells and the xenograft in athymic mice. 22311160 2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE Lapatinib inhibits receptor phosphorylation and cell growth and enhances antibody-dependent cellular cytotoxicity of EGFR- and HER2-overexpressing esophageal cancer cell lines. 21207425 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease CTD_human We investigated whether this EGFR polymorphism is associated with prognosis in patients with esophageal cancer after concurrent chemoradiotherapy (CCRT) and esophagectomy. 21298351 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease CTD_human Polymorphism in epidermal growth factor receptor intron 1 predicts prognosis of patients with esophageal cancer after chemoradiation and surgery. 21298351 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease CTD_human Targeting the human EGFR family in esophagogastric cancer. 21468131 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE Polymorphism in epidermal growth factor receptor intron 1 predicts prognosis of patients with esophageal cancer after chemoradiation and surgery. 21298351 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease CTD_human The EGFR CA repeat genetic polymorphism may act as a valuable molecular predictor of clinical outcome of esophageal cancer after CCRT and esophagectomy, especially in those with good response to CCRT. 21298351 2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE Interaction of EGFR 497Arg>Lys with EGF +61A>G polymorphism: modulation of risk in esophageal cancer. 18773861 2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE Identification of EGFR mutations in esophageal cancer. 17142003 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE Mutations of EGFR were identified in two esophageal cancers (11.7%), three cases of Barrett's esophagus (14.2%), and two pancreatic cancers (3.6%). 16857803 2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE While more primary esophageal tumors remain to be screened for the mutations at the tyrosine kinase domain of EGFR, current observation implies that gefitinib may be worth further investigation for treatment of esophageal cancers. 16357520 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE The selection of esophageal cancer patients for future studies with EGFR-TKIs based on the level of EGFR expression in their tumors or SCC histology should be considered. 16575012 2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 GeneticVariation disease BEFREE These data suggest that EGF-R and p53 mutation may be used as both outcome predictors and targets for molecular therapy for esophageal cancer. 14695149 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 AlteredExpression disease BEFREE Quantitative c-erbB-2 but not c-erbB-1 mRNA expression is a promising marker to predict minor histopathologic response to neoadjuvant radiochemotherapy in oesophageal cancer. 15213712 2004
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.600 Biomarker disease BEFREE To evaluate which molecular biological factors are related to patients' prognosis and recurrence, we checked p53, p16, p21/Waf1, cyclin D1, Ki-67, epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), Mdm2, Bcl2, E-cadherin and MRP1/CD9 by means of immunohistochemical analysis in 116 cases of oesophageal cancer (R0). 10376985 1999