Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE MiR-21 affects the sensitivity of esophageal cancer to cisplatin through targeting PDCD4. 30840273 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Dysregulation of miR-203-3p and miR-21-5p has been identified in esophageal cancer (EC). 30134284 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 GeneticVariation disease BEFREE In addition to known somatic miR-142 mutations in hematologic cancers, we describe novel somatic miR-21 mutations in esophageal cancers impacting downstream miRNA targets. 30302893 2019
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Multiple lines of evidence indicate that the presence, absence, or deregulation of several circulating miRNAs (i.e., let-7a, miR-21, miR-93, miR-192a, miR-18a, and miR-10b for gastric cancer, and miR-21, miR-375, miR-25-3p, miR-151a-3p, and miR-100-3p for esophageal cancer) are associated with initiation and progression of gastric and esophageal cancers. 29923196 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE To evaluate the diagnostic potential of a six microRNAs (miRNAs) panel consisting of miR-21, miR-144, miR-107, miR-342, miR-93 and miR-152 for esophageal cancer (EC) detection. 29380534 2018
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE The expression levels of miR-21, miR-31, miR-93 and miR-375 were different when Zn levels were varied in EC cell lines, but only miR-21 and miR-375 were associated with patient characteristics and prognosis in patients with EC from an area of China with a high incidence of EC. 27885434 2017
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Thus, exosome-shuttling miR-21 may become a potential biomarker for prognosis among esophageal cancer patients. 27035745 2016
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE We selected 5 miRNAs (miRNA-21, -143, -145, -196a and let-7) based on the available literature, and described their potential role in regulating pathways that are deregulated in esophageal cancer. 26755856 2016
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Evaluation of miR-21 and miR-375 as prognostic biomarkers in esophageal cancer. 26481465 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Our results support a prognostic role for miR-21 in EC. 26125864 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 AlteredExpression disease BEFREE Fluorescence quantitative polymerase chain reaction analysis was used to detect the expression of miR-21 in human esophageal tissues, adjacent tissues, and an esophageal cancer cell line (TE-13). 26345812 2015
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 AlteredExpression disease BEFREE Up-regulation of miR-21 and down-regulation of miR-375 can predict unfavourable prognosis in esophageal cancer. 24680681 2014
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Differentially expressed miRNA analysis selected four miRNAs associated with EAC and ESCC, among which hsa-miR-21 and hsa-miR-202 were shared by both diseases. hsa-miR-202 was reported for the first time to be associated with esophageal cancer in the present study. 25098614 2014
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Inhibition of miR-21 may form a novel therapeutic strategy to increase the radiosensitivity of esophageal cancer. 22958183 2014
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Nicotine upregulates microRNA-21 and promotes TGF-β-dependent epithelial-mesenchymal transition of esophageal cancer cells. 24756761 2014
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 AlteredExpression disease BEFREE Taken together, our findings suggest that miR-203 may act as novel tumor suppressor in esophageal cancer through down-regulating the expression of Ran and miR-21. 24001611 2014
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 AlteredExpression disease BEFREE A co-culture system of normal fibroblasts and esophageal cancer cells was used to determine the effects of fibroblasts on miR-21 expression levels, and on SCC cell migration and invasion. 24039846 2013
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Saliva supernatant miR-21 may be a novel biomarker for EC. 23464420 2012
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease BEFREE Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer. 22689922 2012
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 Biomarker disease CTD_human Using 98 formalin-fixed, paraffin-embedded samples obtained from patients with esophageal cancer who had received preoperative chemotherapy followed by surgery, we measured expression levels of several miRNAs that are considered to be involved in the regulation of stem cell function (e.g., let-7a, let-7g, miR-21, miR-134, miR-145, miR-155, miR-200c, miR-203, and miR-296) by real-time reverse transcriptase PCR. 21248297 2011
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
0.400 AlteredExpression disease BEFREE MiR-21 expressions were investigated in esophageal cancer cell line Eca109, and 18 pairs of Kazakh's ESCC and adjacent normal tissues by real-time quantitative PCR (qRT-PCR). 21104017 2011