Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Methylation‑associated silencing of miR‑128 promotes the development of esophageal cancer by targeting COX‑2 in areas with a high incidence of esophageal cancer. 30535495 2019
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Evaluating the expression of cyclooxygenase-2 enzyme by immunohistochemistry in normal and tumoral tissue before and after neoadjuvant chemoradiotherapy in patients with esophageal cancer in Khorasan Province. 29893307 2018
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Thus, this meta-analysis was conducted to comprehensively evaluate the impact of COX-2 expression on the prognostic value in patients with EC. 28652771 2017
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE In the present study, we demonstrated that celecoxib antagonized oxaliplatin-induced cytotoxicity and apoptosis independent of COX-2 inhibition in human esophageal cancer cells. 26474693 2016
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Furthermore, treatment of siRNA for APE-1 significantly reduced COX-2 expression and VEGF production in MCP-1-stimulated esophageal cancer cell lines. 24284961 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation disease BEFREE We performed a gene-wide tag SNP-based association study to examine the association of SNPs in PTGS2 and PLA2G2A with ESCC in 269 patients and 269 healthy controls from Taihangshan Mountain, Henan and Hebei Provinces, the rural area of China which has the highest incidence of esophageal cancer in the world. 24641411 2014
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Promising markers that emerged for the prediction of overall survival in esophageal squamous cell cancer included VEGF (18 eligible studies, n=1476, HR=1.85, 95% CI, 1.55-2.21), cyclin D1 (12 eligible studies, n=1476, HR=1.82, 95% CI, 1.50-2.20), Ki-67 (3 eligible studies, n=308, HR=1.11, 95% CI, 0.70-1.78) and squamous cell carcinoma antigen (5 eligible studies, n=700, HR=1.28, 95% CI, 0.97-1.69); prognostic markers for esophageal adenocarcinoma included COX-2 (2 eligible studies, n=235, HR=3.06, 95% CI, 2.01-4.65) and HER-2 (3 eligible studies, n=291, HR=2.15, 95% CI, 1.39-3.33); prognostic markers for uncategorized ECs included p21 (9 eligible studies, n=858, HR=1.27, 95% CI, 0.75-2.16), p53 (31 eligible studies, n=2851, HR=1.34, 95% CI, 1.21-1.48), CRP (8 eligible studies, n=1382, HR=2.65, 95% CI, 1.64-4.27) and hemoglobin (5 eligible studies, n=544, HR=0.91, 95% CI, 0.83-1.00). 24206575 2013
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation disease BEFREE A large number of studies have demonstrated a strong association between COX-2 polymorphisms and EC risk. 21304218 2011
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE The esophageal cancer cell lines (EC9706) that express COX-2 permanently and hepatocellular carcinoma cell lines (SMMC7721) while no expression of COX-2 were studied. 18443952 2008
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease CTD_human We evaluated the effects of specific COX-2 inhibitors, NS-398 and nimesulide, on cell lines of both histological types of OC. 17707579 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Esophageal tissue with a positive expression of p53 or COX-2 was more likely to develop esophageal cancer. 17650224 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Cyclooxygenase-2 expression after preoperative chemoradiotherapy correlates with more frequent esophageal cancer recurrence. 17511025 2007
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer. 16322294 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease CTD_human We analyzed the association of COX-2 mRNA and protein expression with histomorphologic response to neoadjuvant radiochemotherapy in esophageal cancer. 16322294 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Up-regulation of COX-2 mRNA and protein was observed in esophageal cancer cells transfected with heparanase cDNA. 16299228 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 GeneticVariation disease BEFREE These findings indicate that genetic variants in COX-2 may play a role in mediating susceptibility to esophageal cancer. 16083713 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE The association of several clinicopathological parameters with the immunohistochemical expression of COX-2 was analyzed in paraffin-embedded esophageal cancer specimens. 15978332 2005
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Expression of cyclooxygenase-2 (COX-2) in human esophageal cancer and in vitro inhibition by a specific COX-2 inhibitor, NS-398. 15151617 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE These results suggest that COX-2 may be an important factor for esophageal cancer and inhibition of COX-2 may be helpful for prevention and possibly treatment of this cancer. 15259059 2004
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE Increased cyclooxygenase-2 (COX-2) expression has been observed in both squamous cell carcinoma (SCC) and adenocarcinoma (AC) in Western countries, and COX-2 inhibitors have been considered as potential chemopreventive agents for esophageal cancers. 12893070 2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 AlteredExpression disease BEFREE Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. 11821953 2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease BEFREE NS398 decreased cell viability in 2 cyclo-oxygenase-2-positive (COX-2(+)) esophageal cancer cell lines but not in a COX-2(-) cell line. 11410869 2001
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.400 Biomarker disease CTD_human Selective inhibition of cyclooxygenase-2 suppresses growth and induces apoptosis in human esophageal adenocarcinoma cells. 11059772 2000