Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 AlteredExpression disease BEFREE Differential expression of RET isoforms in normal thyroid tissues, papillary and medullary thyroid carcinomas. 31278686 2019
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 AlteredExpression disease BEFREE The activation of NF‑kB and expression of RET/TC in the TC group were significantly increased (P<0.05) and were correlated with the protein expression of Ku80 (P<0.05). 31578590 2019
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE This includes frequently reported gene fusions such as CCDC6/RET (PTC1), PRKAR1A/RET (PTC2) and ETV6/NTRK3 , and gene fusions that are less common in thyroid cancer (TPM3/NTRK1, EML4/ALK and EML4/NTRK3). 30668525 2019
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE While RET TK inhibitors (TKIs) are used to treat thyroid cancer and are in clinical trials for RET fusion-positive non-small cell lung cancer, the impact of mutations in the RET kinase domain on drug sensitivity is largely uncharacterized. 29908090 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE RET mutation heterogeneity in primary advanced medullary thyroid cancers and their metastases. 29515777 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE The identification of kinase fusions in thyroid carcinomas helps to expand our knowledge about the landscape of oncogenic alterations in PTC. 29046324 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE Furthermore, our KDR gene fusion network analysis revealed six of the seven kinases with the highest DoF scores (ALK, BRAF, MET, NTRK1, NTRK3 and RET) were all observed in thyroid carcinoma. 28013235 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE Several multikinase inhibitors with activity against RET have been explored in the clinic, and confirmed responses to targeted therapy with these agents have been observed in patients with RET-rearranged lung cancers or RET-mutant thyroid cancers. 29134959 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE Several drugs targeting RET have been approved by the FDA for the treatment of cancer: (i) cabozantinib and vandetanib for medullary thyroid carcinomas and (ii) lenvatinib and sorafenib for differentiated thyroid cancers. 29284153 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE These results confirm that PATZ1 downregulation has a critical role in thyroid carcinogenesis, showing that it cooperates with RET/PTC1 in thyroid cancer progression. 29584698 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE <i>In vivo</i>, BLU-667 potently inhibited growth of NSCLC and thyroid cancer xenografts driven by various <i>RET</i> mutations and fusions without inhibiting VEGFR2. 29657135 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE In the present study, we investigated whether the oncogenic RET mutants RET2A (C634R) and RET2B (M918T) were regulated by LRIG1, and the possible effects of LRIG1 expression in thyroid cancer were investigated in three different clinical cohorts and in a RET2B-driven mouse model of MTC. 29436694 2018
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE Although the mechanisms of cellular injury and repair resulting from ionizing radiation are well described, the genomics of radiation-induced tumours are still relatively poorly understood, with some exceptions, such as RET rearrangement in thyroid carcinomas following iodine-131 exposure and MYC amplification in cutaneous angiosarcoma following chest wall irradiation for breast cancer. 27960236 2017
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE To assess the therapeutic potential of AL3810 in treating thyroid cancer involving RET gene fusion, we showed that AL3810 (1-10 μmol/L) dose-dependently inhibited the proliferation of RET-driven Baf3 cell line Baf3-CCDC6-RET, and the auto-phosphorylation of RET in these cells. 28795691 2017
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE Dysregulated activation of RET kinase, either through point mutations or gene fusions, is accountable for a significant fraction of thyroid carcinomas, as well as a minor population of lung cancers. 27646564 2017
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 AlteredExpression disease BEFREE RET is frequently mutated and constitutively activated in familial and sporadic thyroid carcinomas. 27872141 2017
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE KIF5B/RET Rearrangement in a Carcinoma of the Thyroid Gland: A Case Report of a Fatal Disease. 28911147 2017
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE Identification of Three Novel Fusion Oncogenes, SQSTM1/NTRK3, AFAP1L2/RET, and PPFIBP2/RET, in Thyroid Cancers of Young Patients in Fukushima. 28351223 2017
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE The molecular basis for RET tyrosine-kinase inhibitors in thyroid cancer. 28911727 2017
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 AlteredExpression disease BEFREE These data provide the first evidence of a direct link between IDO1 expression and the oncogenic activation of RET in thyroid carcinoma and describe the involved signal transduction pathways. 27994058 2017
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE A comprehensive overview of the role of the RET proto-oncogene in thyroid carcinoma. 26868437 2016
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE We evaluated the best tagging SNPs from our previous PTC study and additionally included SNPs in or near FOXE1 and NKX2-1 genes, known susceptibility loci for thyroid cancer. 27207655 2016
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE RET, BRAF and other protein kinases have been identified as major molecular players in thyroid cancer. 27058903 2016
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 Biomarker disease BEFREE This substance also significantly suppresses growth of thyroid cancer-derived TT cell lines and Ba/F3 cells transformed with various RET mutants. 26652860 2016
Entrez Id: 5979
Gene Symbol: RET
RET
0.800 GeneticVariation disease BEFREE RET mutation and increased angiogenesis in medullary thyroid carcinomas. 27402614 2016