Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Overall, our results elucidated for the first time that TIPE2 sensitizes osteosarcoma cells to cis-platin through downregulation of MDR1 and may be a novel target in osteosarcoma therapy. 30114619 2018
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells. 28693150 2017
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Our findings suggest that multidrug resistant osteosarcoma cells are able to spread their ability to resist the effects of doxorubicin treatment on sensitive cells by transferring exosomes carrying MDR-1 mRNA and its product P-glycoprotein. 27176642 2016
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE In conclusion, icariin possesses a reversal effect on multidrug resistance in MG-63/DOX cells through down-regulation of the MDR1 and the PI3K/Akt pathway, and has the potential to be an adjunct to chemotherapy for osteosarcoma. 25747987 2015
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Our data demonstrate a role for Trps1 in the regulation of MDR1 expression in osteosarcoma. 24491996 2014
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 GeneticVariation disease BEFREE Overexpression of the mdr1 gene encoding P-glycoprotein (Pgp) exerts a major role in reducing the effectiveness of cytotoxic therapy in osteosarcoma. 21780101 2012
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE Anti-MDR1 siRNA restores chemosensitivity in chemoresistant breast carcinoma and osteosarcoma cell lines. 21868524 2011
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE In the osteosarcoma cell lines, etoposide and doxorubicin were better inducers of P450 3A4 and MDR1 than rifampin. siRNA against PXR down-regulated P450 3A4 expression only in the osteosarcoma cell line. 17279585 2007
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE In this study the U2OS human osteosarcoma cell line and its multidrug resistant (MDR) subline that overexpresses MDR-1 gene, MDR-U2OS, have been analyzed for their responsiveness to TRAIL. 15547696 2004
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Expression profiling of osteosarcoma cells transfected with MDR1 and NEO genes: regulation of cell adhesion, apoptosis, and tumor suppression-related genes. 12695554 2003
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE This study represents the first prospective assessment of the prognostic value of MDR1 mRNA expression in patients with newly diagnosed extremity osteosarcoma. 10894867 2000
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE MDR1 gene-transfected osteosarcoma cell clones, showing different levels of P-glycoprotein expression, were analysed for their in vitro characteristics and their tumorigenic and metastatic ability in athymic mice. 9989824 1999
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 Biomarker disease BEFREE In this study, we analyzed the subcellular localization of P-glycoprotein, in a series of U-2 OS osteosarcoma cell clones transfected with MDR1 gene in order to verify whether the nucleus is a constant site for the localization and functional activity of P-glycoprotein, and in which way some aspects of cell morphology related to MDR depend on the subcellular P-glycoprotein localization rather than on the exposure to the selective drug. 10321019 1999
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Nuclear expression of YB-1 is correlated with MDR-1 gene expression in breast cancer and osteosarcoma. 10597187 1999
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE These results suggest that P-Gp/MDR1 overexpression is related to multidrug resistance in human osteosarcoma in vivo. 9458350 1998
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE We have shown previously that overexpression of the MDR1 gene product P-glycoprotein is the most important predictor of an adverse clinical course in patients with osteosarcoma. treated with chemotherapy. 8625324 1996
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE Resistance to several cytotoxic agents (MultiDrug Resistance MDR), including anthracyclines, vinca alkaloids and epipodophylline derivatives can occur in human osteosarcoma (OS) cells, detected by the overexpression of a 170 kD glycoprotein (p170), as a result of increased expression of the MDR gene (mdr1). 8669809 1996
Entrez Id: 23158
Gene Symbol: TBC1D9
TBC1D9
0.100 AlteredExpression disease BEFREE The results of this pilot study suggest that a larger scale prospective investigation of the effect of mdr1 gene expression on outcome in osteosarcoma is warranted. 8100852 1993