Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE In conclusion, these results testified that Ras-ERK1/2 signalling promoted the development of OS by mediating H4K12ac through MDM2-mediated HAT1 degradation. 30942624 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE Circular RNA circ_0102049 promotes cell progression as ceRNA to target MDM2 via sponging miR-1304-5p in osteosarcoma. 31727503 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE We retrospectively reviewed 13 DLOS patients (six men, seven women; median age 32 years (interquartile range (IQR) 27 to 38)) diagnosed using the following criteria: the histological coexistence of low-grade and high-grade osteosarcoma components in the lesion, and positive immunohistochemistry of mouse double minute 2 homolog (MDM2) and cyclin-dependent kinase 4 (CDK4) associated with MDM2 amplification. 31154837 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53<sup>wt</sup> osteosarcoma cells. 30715803 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE These findings from the study demonstrated that Ras-ERK1/2 signaling could promote the development of OS via regulating H2BK12ac through MDM2-mediated CBP degradation. 31695502 2019
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE Consistent Amplification of FRS2 and MDM2 in Low-grade Osteosarcoma: A Genetic Study of 22 Cases With Clinicopathologic Analysis. 30001240 2018
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 AlteredExpression disease BEFREE These mice did not develop malignancies; however, these animals and the MG63 human osteosarcoma cell line with high levels of Mdm2 showed an increase in bone mineralization. 30011084 2018
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 AlteredExpression disease BEFREE GRIM-19 was proved to modulate radiation-induced osteosarcoma cells apoptosis in a p53 dependent manner by mediating MDM2 activity, which sheds light on the development of GRIM-19-based molecular target therapy on osteosarcoma. 30005830 2018
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE A few cases of ESOS with MDM2 amplification have also been reported, suggesting some similarity to skeletal low-grade osteosarcoma such as parosteal osteosarcoma, where MDM2 is often amplified. 28235629 2017
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE Five fibroblastic high-grade osteosarcoma subtypes showed MDM2 amplification, including 2 with a microscopic appearance of high-grade osteosarcoma with part low-grade osteosarcoma (differentiated/dedifferentiated osteosarcoma) and MDM2 overexpression. 26997440 2016
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 GeneticVariation disease BEFREE In conclusion, the present meta-analysis indicates that MDM2 rs1690916 and rs2279744 cannot be considered as genetic risk factors for OS susceptibility in the different populations. 27438225 2016
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 GeneticVariation disease BEFREE Results from this study indicated that the allele-A and genotype-AA of MDM2 c.346G>A genetic variant could be an increased risk factor for the susceptibility to osteosarcoma and might be used as a potential molecular marker for evaluating the risk of osteosarcoma. 25551700 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE Using the SJSA-1 osteosarcoma cell line which harbors an amplified MDM2 gene and wild-type p53, we have investigated the acquired resistance mechanisms both in vitro and in vivo to SAR405838. 26070072 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE Therefore, when compared with low-grade central and parosteal osteosarcomas, MDM2 and CDK4 markers cannot be used diagnostically to differentiate this subtype of osteosarcoma. 25680902 2015
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 GeneticVariation disease BEFREE Future studies are needed to further assess the effects of MDM2 polymorphisms on the risk and survival of osteosarcoma. 24122202 2014
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 GeneticVariation disease BEFREE Results from this study suggest that MDM2 genetic variants are potentially related to OS susceptibility in Chinese Han population, and might be used as molecular markers for assessing OS susceptibility. 23933591 2013
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE On the other hand, late events such as the loss of RB1 and gain of MDM2, crucial regulators of cell cycle, appear to be related to the final mechanisms contributing to the metastatic establishment of osteosarcoma. 23845465 2013
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE MDM2 and CDK4 immunohistochemical coexpression in high-grade osteosarcoma: correlation with a dedifferentiated subtype. 22301501 2012
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 AlteredExpression disease BEFREE We found that the HDMX-S/HDMX-FL ratio associated with common somatic genetic lesions connected with p53 inhibition, such as p53 mutation and HDM2 overexpression in osteosarcoma cell lines. 22700878 2012
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE The results showed that MDM2 and/or CDK4 immunoreactivity was present in 89% of low-grade osteosarcoma specimens. 21336260 2011
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE In an effort to identify novel Mdm2 binding partners, we performed a large-scale immunoprecipitation of Mdm2 in the osteosarcoma U2OS cell line. 20547751 2010
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 Biomarker disease BEFREE Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. 20196171 2010
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 GeneticVariation disease BEFREE The study provides evidence supporting the association of MDM2 SNP309 with high-grade osteosarcoma risk in females and shows that TP53 Arg72Pro has a prognostic value for overall survival and EFS in osteosarcoma patients. 19451596 2009
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 AlteredExpression disease BEFREE We found that adenovirus-wt p53 (Ad-wt p53) induces significant apoptosis in HT1080 fibrosarcoma cells expressing low levels of Mdm2, but fails to induce apoptosis in SJSA osteosarcoma cells expressing high levels of Mdm2. 15026814 2004
Entrez Id: 4193
Gene Symbol: MDM2
MDM2
0.100 AlteredExpression disease BEFREE MDM2 alteration and p21WAF1 expression were not observed in any of the cases of MFH-like OS. 12181274 2002