Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE MicroRNA-29b sensitizes osteosarcoma cells to doxorubicin by targeting matrix metalloproteinase 9 (MMP-9) in osteosarcoma. 30840264 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Amentoflavone significantly inhibits tumor growth and reduces protein levels of phospho-extracellular signal-regulated kinase (P-ERK), nuclear factor-kappaB (NF-κB) p65 (Ser536), vascular endothelial growth factor (VEGF), matrix metallopeptidase 9 (MMP-9), X-linked inhibitor of apoptosis protein (XIAP), and cyclin-D1 in osteosarcoma in vivo. 31262893 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Furthermore, it altered the expression of various proteins associated with cell growth (Ki67, p21, cyclin A, cyclin E, and cyclin-dependent kinase 2), migration (matrix metalloproteinase-2 [MMP-2], MMP-9, and tissue inhibitor of metalloproteinase-1), apoptosis (poly[ADP-ribose] polymerase 1 and caspase 3), and drug resistance (p-glycoprotein 1, lung resistance-related protein 1, growth arrest and DNA damage-45α, glutathione S-transferase π, and heat shock protein 27) in paclitaxel-resistant osteosarcoma cells. 31106479 2019
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Next, we used lentivector packaging method to overexpress MMP-9 and found that overexpression of MMP-9 promoted OS cell migration. 29068478 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE The results of meta-analysis indicated that MMP-9 may be a prognostic biomarker guiding the clinical therapy for OS. 30383677 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE In addition, 14‑3‑3β knockdown significantly decreased the protein expression levels of β‑catenin, cyclin D1, v‑myc avian myelocytomatosis viral oncogene homolog and matrix metallopeptidase 9 in osteosarcoma MG63 cells. 29207109 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Suppression of miR-506-3p in osteosarcoma led to increased expression of RAB3D, which in turn led to increased CDK4 (cyclin-dependent kinase 4) and MMP9 (matrix metalloprotein 9) activities. 29905536 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE After SOX4 gene silencing, the protein expression levels of Bax, Caspase-3, and P53 in osteosarcoma cells were significantly elevated, while the protein expression levels of Bcl-2, MMP2, and MMP9 were obviously decreased. 29038881 2018
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Notably, MMP‑9 and NF‑κB expression were downregulated by treatment with AbBmi‑1 in MG‑63 osteosarcoma cells. 28983587 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE A reporter gene assay demonstrated that BITC, PEITC, and SFN suppressed TAP-induced MMP-9 expression by inhibiting AP-1 and NF-κB in U20S osteosarcoma cells. 28969043 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Taking in account that β1 Integrin and MMP-9 and -13 have been correlated with the invasiveness of osteosarcoma, considering that NCPA affects the invasiveness of 143B cell line, we suggest that this molecule could affect the osteosarcoma metastatic ability. 27931795 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE High levels of CUL1 promote osteosarcoma progression via up-regulation of MMP9 expression. 28315506 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE However, the prognostic value of MMP-9 on survival of osteosarcoma patients still needs further large-scale trials to be clarified. 26239566 2017
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE In this study, we found a pronounced suppressive effect of glucosamine sulfate particularly on MMP-3 and also MMP-9 mRNA and protein levels in osteosarcoma cell lines in vitro. 27562075 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 GeneticVariation disease BEFREE We used bioinformatics tools to identify possible binding sites of miR-491 in the 3'UTR of MMP9 and 30 OS tissue samples were collected and divided into two groups based on the rs1056629 genotype (AA, N=20; AC, N=8; and CC N=2). 27023472 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE A shift from MMP9 to predominant MMP2 activity is associated with poor response to chemotherapy suggesting that the ratio of MMP2/MMP9 activity might be a valuable and easily accessible marker to predict the response to chemotherapy in osteosarcoma. 26979530 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE The aim of this study was to investigate the association of CXCR4 and MMP9 expression with clinicopathological features and pulmonary metastasis in osteosarcoma. 26546437 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE We conclude that CD151 knockdown inhibits the expression of MMP9 through the GSK-3β/β‑catenin pathway and also inhibits OS migration and invasion in vitro and metastasis in vivo in highly metastatic OS. 26707073 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Inhibition of PREX2a also markedly suppressed the invasion and migration of OS cells, at least partly by suppressing the protein expression of matrix metalloproteinase (MMP)2 and MMP9. 26718453 2016
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE Metformin suppressed OS MG63 cell proliferation in a dose- and time-dependent manner and markedly blocked anti-metastatic potentials, migration, and invasion, by downregulating matrix metalloproteinase 2 (MMP2) and MMP9. 26164004 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Our findings suggested that HEY1 augmented the metastasis of osteosarcoma via upregulation of MMP9 expression. 25742474 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Furthermore, miR-142 inhibited osteosarcoma cell invasion by inducing E-cadherin expression and reducing expression of matrix metalloproteinase 2 (MMP2) and MMP9. 25530132 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 AlteredExpression disease BEFREE Furthermore, we determine the functional relevance of Beclin-1 knockdown to osteosarcoma cell growth, migration, and invasion, and investigate the expression levels of matrix metallopeptidase-2 (MMP-2), MMP-9, phosphoinositide 3-kinase p85α (PI3Kp85α), and phosphorylated AKT (p-AKT). 25427639 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE This downregulation of RECK in advanced grades of osteosarcoma and metastatic grades was also associated with the increased expression of invadosome-specific markers like MMP9, phospho-FAK, and integrins, suggesting the complex contributions of RECK in the prevention of metastasis and its downregulation as a causative factor in osteosarcoma metastasis. 26130413 2015
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
0.100 Biomarker disease BEFREE In vitro and in vivo experiments demonstrated that knockdown of HOTAIR could notably suppress cellular proliferation, inhibit invasion and decrease the secretion of MMP2 and MMP9 in osteosarcoma. 25728753 2015