Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 14
Gene Symbol: AAMP
AAMP
0.010 Biomarker phenotype BEFREE According to our findings, AAMP knockdown inhibited lung cancer cell proliferation and inhibited lung cancer cell tumorigenesis in the mouse xenograft model. 31075398 2019
Entrez Id: 15
Gene Symbol: AANAT
AANAT
0.010 Biomarker phenotype BEFREE We concluded that O-GlcNAcylation of YY1 stimulates tumorigenesis in CRC cells by targeting SLC22A15 and AANAT, suggesting that YY1 O-GlcNAcylation might be a potential effective therapeutic target for treating CRC. 30715269 2019
Entrez Id: 284837
Gene Symbol: AATBC
AATBC
0.010 Biomarker phenotype BEFREE Moreover, mouse xenograft model revealed that knockdown of AATBC led to suppress tumorigenesis in vivo. 25473900 2015
Entrez Id: 26574
Gene Symbol: AATF
AATF
0.020 Biomarker phenotype BEFREE Importantly, Che-1 and p53 proteins are components of the DNA damage response machinery that maintains genome integrity and prevents tumorigenesis. 27639846 2016
Entrez Id: 26574
Gene Symbol: AATF
AATF
0.020 Biomarker phenotype BEFREE The transcriptional cofactor Che-1 is an RNA polymerase II (Pol II) which is involved in tumorigenesis, such as breast cancer and multiple myeloma. 27012205 2016
Entrez Id: 18
Gene Symbol: ABAT
ABAT
0.010 AlteredExpression phenotype BEFREE The effect of ABAT expression on BLBC cells was determined by <i>in vitro</i> and <i>in vivo</i> tumorigenesis and a lung metastasis mouse model. 30662552 2019
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.020 Biomarker phenotype BEFREE Like p53 loss, ablation of ABCA1 promotes murine liver tumorigenesis and is associated with increased SREBP-2 maturation. 30580964 2019
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.020 Biomarker phenotype BEFREE Herein, we explored potential roles in melanoma tumorigenesis for host scavenger receptor class B, type 1 (SR-B1), and ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1), all mediators of apoA-I and HDL sterol and lipid transport function. 29069761 2017
Entrez Id: 26154
Gene Symbol: ABCA12
ABCA12
0.010 AlteredExpression phenotype BEFREE In conclusion, these results suggest that lnc-ABCA12-3 is a novel oncogene in tumorigenesis and that its high expression is related to a poor prognosis for patients with ESCC. lnc-ABCA12-3 promotes cell migration, invasion, and proliferation via the regulation of FN1 in ESCC. 31512786 2020
Entrez Id: 24
Gene Symbol: ABCA4
ABCA4
0.010 Biomarker phenotype BEFREE To elucidate the role of URI/RMP during oncogenesis of multiple malignancies, especially the tumors of reproductive system, we analyzed URI/RMP expression in a TMA containing multiple reproductive system tumors. 23573313 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 PosttranslationalModification phenotype BEFREE The promoter methylation of MDR1 seems to have a significant role in carcinogenesis and tumor progression in the stomach. 19331170 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE In this study, we characterized the expression of multidrug-resistance mdr1 gene, which may play a role in tumorigenesis and multidrug resistance in head and neck cancer. 12460464 2002
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE This study suggests that low ABCB1 mRNA levels are an early event in CRC development and that the two polymorphisms affect ABCB1 mRNA levels whereas low NFKB1 mRNA levels occur later in carcinogenesis. 23977225 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE In combination with cell proliferative activities of c-myc and cyclin D1, MDR1 may initiate colorectal tumorigenesis by suppressing cell death pathways programmed in intestinal epithelial cells. 10987283 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation phenotype BEFREE The multidrug resistance 1 gene (MDR1) C3435T polymorphism has been demonstrated to influence the P-glycoprotein (P-gp) activity level which is related to inflammation and carcinogenesis. 24815441 2014
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation phenotype BEFREE Thus, this MDR1 polymorphism does not seem to play an important role in colorectal carcinogenesis in this population. 19250544 2009
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE The multidrug resistance gene 1 (MDR1) seems to play a role in the carcinogenesis of colorectal tumors. 17146660 2007
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE Taken together, miR-501 induces doxorubicin resistance and enhances the tumorigenesis of gastric cancer cells by suppressing BLID. miR-501 might be a potential target for doxorubicin resistance and gastric cancer therapy. 30195794 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE Meanwhile, MDR1 gene expression in gallbladder carcinoma is correlated with some biological characteristics, takes part in the carcinogenesis of gallbladder tissues, and acts as a valuable biomarker of prognosis. 15138130 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression phenotype BEFREE We conclude that P-gp is differentially expressed during oral tumorigenesis, and may be an indicator of the biological behavior of oral malignancies. 9036881 1997
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation phenotype BEFREE The C3435T (rs1045642) polymorphism, located in multi-drug resistance gene 1 (MDR1), has demonstrated its role in decreasing the P-gp activity level which is related to the carcinogenesis. 24070710 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE Reactive oxygen species (ROS) are closely related to tumorigenesis and P-glycoprotein (P-gp) is highly expressed in various cancers. 30972167 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE In conclusion, this study found that ABCC2 and ABCG2 expression levels were altered already in mild/moderate dysplasia in carcinogenesis suggesting that these ABC transporters are involved in the early steps of carcinogenesis as previously reported for ABCB1. 25793771 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE P-glycoprotein might not be involved in the carcinogenesis of H. pylori-related gastric cancer. 18644389 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker phenotype BEFREE The P-glycoprotein (P-gp) plays an important role in carcinogen distribution and is connected with cell differentiation and apoptotic processes leading to carcinogenesis. 17300681 2007