Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification phenotype BEFREE In conclusion, hMLH1 and O6-MGMT promoter methylation are frequently present in AH, and thus considered to be early events in the carcinogenesis of EC, whereas P16 promoter methylation was mainly present in EC, and not in precursor lesions supporting a late event in the carcinogenesis. 30430425 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy. 31611375 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression phenotype BEFREE Down-regulation of p16INK4a and miR-146b-5p contributes to tumorigenesis in osteosarcoma (OS). 30643010 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE In the FFPE samples, the immunohistochemistry of p16, which is considered appropriate to assess HPV-driven carcinogenesis in OPSCC according to the 8th American Joint Committee on Cancer TNM classification, may not be specific enough to become the diagnostic standard in the perspective of treatment deintensification. p16 may play a safer role in combination with another highly sensible assay. 30747478 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Loss of p16 allows for uninhibited cell cycle progression, bypass of OIS, and tumorigenesis. 31433975 2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Hepatitis C Virus core+1/ARF Protein Modulates the Cyclin D1/pRb Pathway and Promotes Carcinogenesis. 29444947 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification phenotype BEFREE Our findings indicate CDKN2A methylation is involved in the carcinogenesis, progression, and metastasis of HNSCC. 30355925 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Our study investigates the prevalence, prognostic, and clinicopathologic features of HPV-related oropharyngeal cancer in Northeast China and elucidates the involvement of p16 in the tumorigenesis and progression of OPSCC. 30310820 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE An impaired cell-cycle control and genetic material organization are crucial elements of carcinogenesis. p16 is a tumor suppressor protein which decelerates promotion of the cells from G<sub>1</sub> to S phase, whereas special AT-rich sequence-binding protein 1 (SATB1) is a nuclear matrix protein that binds to specific regions of the DNA and ensures its proper organization and function. 29936452 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression phenotype BEFREE The activation of CDKN2A pathway in p53<sup>S/S</sup> MEF and tumors, and the accumulation of p19<sup>ARF</sup> protein in tumor tissues suggested p19<sup>ARF</sup> might contribute to the accumulation of mutant p53S protein in the tumor and promote tumorigenesis. 28949402 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Differences in tumorigenesis disappeared when female GBM astrocytes are also rendered null for p16 and p21. 29458417 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation phenotype BEFREE Although some LM-BN share several significant genetic alterations with leiomyosarcoma, including p16 and p53, the underlying tumorigenesis of LM-BN remains largely unknown. 28863073 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation phenotype BEFREE This study showed that p16 and MDM2 polymorphisms do not play a decisive role in tumorigenesis, but some genotypes of these polymorphisms might be associated with follow-up characteristics of prolactinoma. 28438863 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE The results of the study revealed that p16 was negatively regulated by EZH2 in ovarian cancer, and that p16 and EZH2 are important in the tumorigenesis of ovarian cancer. 29435063 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression phenotype BEFREE Finally, the absence of differences in p53 and p16 expressions is at variance with other epithelia where the classical pathway is associated with human papillomavirus infection and can be explained by the fact that both AK pathways share identical mechanisms of actinic oncogenesis. 28796927 2018
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Our findings indicate that CDKN2A methylation has a vital role in EC tumorigenesis and could be a biomarker for early diagnosis of EC. 28637022 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE The current paradigm is that p16 and RB1 function in a linear pathway to suppress tumorigenesis; however p16 is preferentially lost in human cancers suggesting that p16 has critical tumor suppressive functions not mediated through RB1. 28414317 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation phenotype BEFREE Their role in c-MYC-driven colorectal carcinogenesis is unclear, as p19ARF deletion does not accelerate APC loss-triggered intestinal tumorigenesis. 27617574 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification phenotype BEFREE Taken together, meta-analysis results support P16INK4a hypermethylation as an epigenetic marker for the progression of cervical carcinogenesis. 27669738 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Ninety percent of examined murine B-ALL tumors showed loss of the wild-type <i>Ink4a/Arf</i> locus without acquisition of highly recurrent cooperating events, underscoring the role of <i>Ink4a/Arf</i> in restraining Kras-driven oncogenesis in the lymphoid compartment. 29296886 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 AlteredExpression phenotype BEFREE Consistent with this notion, re-instatement of constitutive p19ARF expression in the HB model completely suppressed tumorigenesis. 28820908 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE The tumor suppressors ID3, ARID1A, APC, and CDKN2A are frequently impaired also on the protein level and thus potentially affect ACC tumorigenesis. 29109526 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 Biomarker phenotype BEFREE Our results support the hypothesis that unidentified nevogenic genes are co-inherited with CDKN2A and may influence carcinogenesis. 28830827 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 GeneticVariation phenotype BEFREE Therefore, in this study, we explored the possible association between the two important G1 cell cycle regulatory genes p16 and p53 and environmental risk factors and risk of esophageal carcinogenesis. 28459370 2017
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
0.400 PosttranslationalModification phenotype BEFREE Our data confirm previous observations and suggest that losses of the MLH1 and CDKN2 genes and alterations of the TIMP3 gene play an important role in head and neck carcinogenesis. 27696595 2017