Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 AlteredExpression phenotype BEFREE Collectively, our study showed that BRAF-activated noncoding RNA promotes pancreatic cancer tumorigenesis through miR-195-5p/Wnt/β-catenin axis may serve as a potential target for diagnostics and therapeutics in pancreatic cancer. 31769353 2020
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE Mutations in EGFR, ERBB2, NRAS, and BRAF are early clonal genomic events during carcinogenesis of lung adenocarcinoma, whereas TP53 and cell mobility, gap junction, and metastasis-related genes may be late events associated with subclonal diversification and neoplastic progression. 31446140 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE BRAF plays an indispensable role in activating the MEK/ERK pathway to drive tumorigenesis. 31015455 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE In contrast, pathogenic variants classically associated with tumorigenesis in genes like TP53 and BRAF are also present in CD but with low incidence (12.5% and 7%). 31717455 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE The pathogenesis and molecular mechanism of thyroid tumors are yet remains elucidated, in spite of activating RET, RAS and BRAF carcinogenesis have been well introduced. 31472323 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE In addition, we find that C-Raf is critical for mutant H-Ras-driven signaling and that events stabilizing B-Raf/C-Raf dimerization, such as Raf inhibitor treatment or certain B-Raf mutations, can allow mutant H-Ras to engage B-Raf with increased affinity to promote tumorigenesis, thus revealing a previously unappreciated role for C-Raf in potentiating B-Raf function. 31606273 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE RAS/BRAF mutations of colorectal cancer (CRC) play a crucial role in carcinogenesis and cancer progression and need to be considered for the therapeutic strategy choice. 31773354 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Interestingly, prior to BRAF mutation, important genes regulating odontogenesis mutated (e.g., corepressor BCOR), possibly playing important roles in tumorigenesis. 30917298 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 AlteredExpression phenotype BEFREE Increasing evidence reported that aberrant expression of <i>BRAF activated non-coding RNA</i> (<i>BANCR</i>) was involved in the tumorigenesis and progression of various malignancies. 31114383 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE Further, we analyzed our model's predictions to better understand the molecular processes underlying synergy and discovered that key regulators of tumorigenesis such as TNFA and BRAF are often targets in synergistic interactions, while MYC is often duplicated. 31222109 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 AlteredExpression phenotype BEFREE Although it is clear that the invasive phenotypes of B-Raf mutated melanoma cells are stringently dependent on B-Raf-MEK-ERK activation, the downstream effector targets that are required for oncogenic B-Raf-mediated melanomagenesis are not well defined. miRNAs have regulatory functions towards the expression of genes that are important in carcinogenesis. 30995246 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Our biochemical characterization of intact BRAF<sup>V600E</sup> together with molecular dynamics (MD) simulations of the BRAF kinase domain and cell-based assays demonstrate that BRAF<sup>V600E</sup> has several unique features that contribute to its tumorigenesis. 31152574 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 AlteredExpression phenotype BEFREE Finally, ionizing radiation and the mutation of oncogenes, such as RAS and BRAF, play a key role in thyroid carcinogenesis through separate and unique mechanisms: they upregulate the expression of two distinct 'professional' ROS-generating systems, the NADPH oxidases DUOX1 and NOX4, which cause DNA damage that may promote chromosomal instability, tumourigenesis and dedifferentiation. 30615595 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE When expressed only in melanocytes, RAC1<sup>P29S</sup> cooperates with oncogenic BRAF or with NF1-loss to promote tumorigenesis. 31257073 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE A previous study identified a novel gene, monopolar spindle protein kinase 1 (Mps1), a downstream target of BRAF<sup>V600E</sup> only, rather than of wild-type BRAF as well, which contributes to tumorigenesis in melanoma. 30854056 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Alterations in the BRAF gene have been reported to play a key role in the tumorigenesis of various tumors. 31147232 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Approximately 15% to 20% of colorectal cancers are developed through the serrated pathway of tumorigenesis, which is associated with BRAF mutation, CpG island methylation phenotype, and MLH1 methylation. 31199922 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Specific mutations of RAF kinases, such as the prevalent BRAF(V600E) mutation in melanoma, or defects in upstream signaling or feedback loops cause decoupled kinase activities which lead to tumorigenesis. 28466200 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 AlteredExpression phenotype BEFREE The tumorigenesis, development, dedifferentiation and metastasis of ATC are closely associated with the activation of various tyrosine cascades and inactivation of tumor suppressor genes, including B-Raf proto-oncogene, serine/threonine kinase<sup>V600E</sup>, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α,tumor protein 53 mutations and telomerase reverse transcriptase mutation. 31555347 2019
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE According to the literature, our data provide evidence of the BRAF and RAS roles in thyroid tumorigenesis, supporting an association between BRAF (V600E) mutations and the more aggressive clinical and pathological features of thyroid tumors. 29435002 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE Further investigation of the CTH gene in colorectal carcinogenesis with regards to KRAS and BRAF mutations or other molecular characteristics of the tumor may be warranted. 29694444 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE Through structural analysis and mechanistic studies with BRAF and mitogen-activated protein kinase (MEK) inhibitors, we describe how kinase-dependent and -independent functions of MAPK signaling components regulate KRAS-driven tumorigenesis and how these insights can be used to treat RAS mutant cancers with small molecule kinase inhibitors. 29440321 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE RAF (rapidly accelerated fibrosarcoma) Ser/Thr kinases (ARAF, BRAF, and CRAF) link the RAS (rat sarcoma) protein family with the MAPK (mitogen-activated protein kinase) pathway and control cell growth, differentiation, development, aging, and tumorigenesis. 30381334 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 GeneticVariation phenotype BEFREE We identified novel genes that are potentially associated with PTC tumorigenesis, as well as aberrations in pathways that led to the distinct pathogeneses of BRAF-mutated PTC and wild-type BRAF PTC, which may provide a new target for PTC therapy. 29753010 2018
Entrez Id: 673
Gene Symbol: BRAF
BRAF
0.400 Biomarker phenotype BEFREE ARHGEF19 interacts with BRAF to activate MAPK signaling during the tumorigenesis of non-small cell lung cancer. 29164615 2018