Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2
Gene Symbol: A2M
A2M
0.040 Biomarker disease BEFREE Binding of α(2)M* to prostate cancer cell surface GRP78 upregulates mTORC1 and mTORC2 activation and promotes protein synthesis in the prostate cancer cells. 23272152 2012
Entrez Id: 2
Gene Symbol: A2M
A2M
0.040 AlteredExpression disease BEFREE We previously reported that advanced prostate cancer (PCa) patients with multiple distant bone metastases had markedly decreased serum α2M levels (<20 mg/dl) and no detection of α2M by immunoelectrophoresis (defined as α2M deficiency). 22576683 2012
Entrez Id: 2
Gene Symbol: A2M
A2M
0.040 Biomarker disease BEFREE Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. 25720493 2015
Entrez Id: 2
Gene Symbol: A2M
A2M
0.040 Biomarker disease BEFREE PSA-alpha-2-macroglobulin complex is enzymatically active in the serum of patients with advanced prostate cancer and can degrade circulating peptide hormones. 29659051 2018
Entrez Id: 100034703
Gene Symbol: AA2
AA2
0.010 GeneticVariation disease BEFREE Subjects carrying TT/AA/AA/AG/ID, TC/AA/AA/AA/II, TT/AA/AT/AA/II and TT/AA/AT/AG/ID genotypes are associated with a decreased risk of PCa. 27609473 2016
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 AlteredExpression disease BEFREE Attenuated ABCA1 expression in androgen-independent cells thus may contribute, in part, to prostate cancer progression. 15520169 2004
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 Biomarker disease BEFREE Fractalkine (FKN) is a membrane‑bound chemokine, which is implicated in the progression of human prostate cancer and skeletal metastasis. 26496926 2015
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 AlteredExpression disease BEFREE Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells. 19531574 2009
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 AlteredExpression disease BEFREE As expected, lycopene treatment (2.5-10 μM) significantly inhibited the proliferation of LNCaP cells during incubation for 96 h. Lycopene significantly increased the protein and mRNA expression of PPARγ and LXRα at 24 and 48 h, while the increased in the expression of ATP-binding cassette transporter 1 (ABCA1) was only evident 96 h. In addition, lycopene significantly decreased cellular total cholesterol levels and increased apoA1 protein expression at 96 h. Incubation of LNCaP cells with lycopene (10 μM) in the presence (20 μM) of a specific antagonist of PPARγ (GW9662) and LXRα (GGPP) restored the proliferation of LNCaP cells to the control levels and significantly suppressed protein expression of PPARγ and LXRα as well as increased cellular total cholesterol levels. 21334870 2012
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.050 AlteredExpression disease BEFREE In human prostate biopsy samples, ABCA1 mRNA expression was ∼2-fold higher in the androgen deprivation therapy group than in subjects with benign prostatic hyperplasia or pretreatment prostate cancer groups. 20671065 2010
Entrez Id: 20
Gene Symbol: ABCA2
ABCA2
0.010 AlteredExpression disease BEFREE Cytotoxicity assays suggested a role for ABCA2 in estramustine and estradiol resistance, and overexpression of ABCA2 is seen in an estramustine-resistant prostate carcinoma line. 15093135 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE These data suggest that drug resistance in human prostate cancer may be multifactorial, with MRP and LRP frequently expressed in prostate cancer cells before antineoplastic drug treatment and P-gp expression occasionally acquired after drug exposure. 11078791 2000
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE The study was focused on the inhibition of MDR by blocking the ADR1 gene expression and through the inhibition of the pump-function of mdr-p-glycoprotein, in human breast cancer cell lines expressing mrp and prostate cancer cell line (PC-3). 15161039 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Hypermethylation was more frequent in PCa than in BPH tissues (EDNRB, 100% versus 88%; TIG1, 96% versus 12%; RARbeta, 95% versus 35%; GSTP1, 93% versus 15%; APC, 80% versus 50%; MDR1, 80% versus 31%; PTGS2, 68% versus 15%; Reprimo, 59% versus 19%; and Annexin2, 4% versus 0%). 18242387 2008
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Overexpressed ABCB1 Induces Olaparib-Taxane Cross-Resistance in Advanced Prostate Cancer. 31075528 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Those stem-like prostate cancer cells show high expression of ABCB1, which encodes multidrug resistance-related protein P-glycoprotein, leading to the Doc-resistance in prostate cancer. 29944470 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 GeneticVariation disease BEFREE These findings suggested that the c.1465C>T polymorphism of MDR1 may be risk factors for prostate cancer in Chinese men. 24085442 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE Steroid derivatives were studied for their growth-inhibitory effect, cytotoxicity, reversal of multidrug resistance, apoptosis induction, and interaction with doxorubicin on multidrug resistant human ATP-binding cassette, sub-family B, member 1 (ABCB1) gene-transfected mouse T-lymphoma cell line, and human PC-3 and LNCaP prostate cancer cell lines in vitro. 25862866 2015
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 PosttranslationalModification disease BEFREE MDR1 promoter methylation levels and frequency significantly increased from NPTs, to HGPIN and to PCa. 24344919 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Because of a possible beneficial effect of a combination of ketoconazole and a chemotherapeutic drug in multidrug resistant cancers, we examined a panel of 11 prostate carcinoma tissues for the expression of the MDR1 gene by an RNA-PCR assay. 7904313 1994
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE LncRNA LOXL1-AS1/miR-let-7a-5p/EGFR-related pathway regulates the doxorubicin resistance of prostate cancer DU-145 cells. 31188543 2019
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE Taken together, these results provide strong evidence that TPL overcomes MDR in prostate cancer cells by downregulating MDR1 expression, and suggest that TPL is a promising agent for prostate cancer therapy, especially for chemoresistant prostate cancer. 23906293 2013
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 AlteredExpression disease BEFREE We hypothesize that early in prostate cancer progression, increased expression of YB-1 may increase P-gp activity which may in turn lower androgen levels in the prostate tumor cells. 15042610 2004
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 Biomarker disease BEFREE A prostate cancer (PC)3 cell line (PC3/R) with acquired doxorubicin-resistance was established. 29434932 2018
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
0.100 PosttranslationalModification disease BEFREE These findings suggest that CpG hypermethylation of MDR1 promoter is a frequent event in prostate cancer and is related to disease progression via increased cell proliferation in prostate cancer cells. 15342374 2004