Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE Widespread prostate-specific antigen (PSA) testing notably increased the number of prostate cancer (PCa) diagnoses. 28555004 2018
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE The incidence of low-risk prostate cancer (PCa) has increased as a consequence of prostate-specific antigen testing. 28318726 2018
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE Prostate cancer (PCa) diagnosis using patient urine samples represents a non-invasive and more convenient method than the conventional biopsy and prostate-specific antigen (PSA) test. 29491074 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 Biomarker disease BEFREE Inherited mutations in DNA-repair genes such as BRCA2 are associated with increased risks of lethal prostate cancer. 28789927 2018
Entrez Id: 6581
Gene Symbol: SLC22A3
SLC22A3
0.200 Biomarker disease BEFREE EMT circulating tumor cells detected by cell-surface vimentin are associated with prostate cancer progression. 28521303 2018
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE Besides clinical stage and Gleason score, risk-stratification of prostate cancer in the pretherapeutic setting mainly relies on the serum PSA level. 28923030 2018
Entrez Id: 6581
Gene Symbol: SLC22A3
SLC22A3
0.200 Biomarker disease BEFREE Oncogenic miR-210-3p promotes prostate cancer cell EMT and bone metastasis via NF-κB signaling pathway. 28693582 2018
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE Sensitivity of HOXB13 as a Diagnostic Immunohistochemical Marker of Prostatic Origin in Prostate Cancer Metastases: Comparison to PSA, Prostein, Androgen Receptor, ERG, NKX3.1, PSAP, and PSMA. 28555048 2018
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE Two key issues in prostate cancer (PCa) that demand attention currently are the need for a more precise and minimally invasive screening test owing to the inaccuracy of prostate-specific antigen and differential diagnosis to distinguish advanced vs. indolent cancers. 28527622 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease BEFREE BRCA2 mutations should be screened early and routinely as markers of poor prognosis: evidence from 8,988 patients with prostate cancer. 28410213 2018
Entrez Id: 6581
Gene Symbol: SLC22A3
SLC22A3
0.200 Biomarker disease BEFREE Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer. 29452232 2018
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 GeneticVariation disease BEFREE T2E transcripts were detected in 31.7% (n=20) of the patients examined, and this was significantly associated with subsequent detection of PC in ASAP patients with a prostate specific antigen (PSA) level of 4-10ng/ml (p=0.045). 29277318 2018
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 AlteredExpression disease BEFREE Highly efficient target therapy is urgently needed for prostate cancer with overexpression of γ-seminoprotein (γ-SM). 28529067 2017
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 GeneticVariation disease BEFREE Our results suggest that rs4962416, previously associated only with prostate cancer, is also associated with PSA levels, with 12% increase for each copy of the minor allele C. The study enabled the replication of the effect for the majority of previously reported genetic variants in a set of clinically relevant prostate cancers. 26773531 2017
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE Androgen/AR is the primary contributor to prostate cancer (PCa) progression by regulating Prostate Specific Antigen (PSA) gene transcription. 28199985 2017
Entrez Id: 7015
Gene Symbol: TERT
TERT
0.200 GeneticVariation disease GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191 2017
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 GeneticVariation disease BEFREE Single-nucleotide polymorphism rs1058205 of KLK3 is associated with the risk of prostate cancer: A case-control study of Han Chinese men in Northeast China. 28272245 2017
Entrez Id: 6581
Gene Symbol: SLC22A3
SLC22A3
0.200 Biomarker disease BEFREE SOX4 induces tumor invasion by targeting EMT-related pathway in prostate cancer. 28466783 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.200 GeneticVariation disease GWASCAT We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer, and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. 27197191 2017
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
0.200 GeneticVariation disease GWASCAT Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. 27262462 2017
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
0.200 GeneticVariation disease GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191 2017
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE Differential blood-based diagnosis between benign prostatic hyperplasia and prostate cancer: miRNA as source for biomarkers independent of PSA level, Gleason score, or TNM status. 26831660 2017
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 AlteredExpression disease BEFREE In a previous population-based study on 3369 European men with self-reported prostate cancer (PCa), it was shown that androgen receptor (AR) haplotype designated H2 was associated with high levels of serum PSA (prostate-specific antigen) concentration, and, at the same time, with low risk for PCa. 28176139 2017
Entrez Id: 6581
Gene Symbol: SLC22A3
SLC22A3
0.200 GeneticVariation disease GWASCAT Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21. 27262462 2017
Entrez Id: 354
Gene Symbol: KLK3
KLK3
0.200 Biomarker disease BEFREE Background One of the kallikrein genes ( KLK3) encodes prostate-specific antigen, a key biomarker for prostate cancer. 27555663 2017