Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
|
0.070 | GeneticVariation | disease | BEFREE | At 10 % cutoff for CDH1 94% of EOC cases were found to be methylated with mean methylation of 45±13.8, whereas for control mean methylation was found to be 7.3±3.7 amongst 16 % methylation positive control samples. | 31653136 | 2019 | ||||
|
0.070 | PosttranslationalModification | disease | BEFREE | CDH1, DLEC1 and SFRP5 methylation panel as a prognostic marker for advanced epithelial ovarian cancer. | 30324802 | 2018 | ||||
|
0.070 | AlteredExpression | disease | BEFREE | Depletion of COX-2, by celecoxib treatment, resulted in attenuated nuclear translocation of Snail, and, in turn, significantly increased E-cadherin in EOC cell line SKOV3, which was established to be due to the reduced binding of Snail onto E-cadherin promoter. | 29932878 | 2018 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | No significant association was detected between the CDH1 3'-UTR +54C/T polymorphism and survival of the patients with EOC. | 27779545 | 2016 | ||||
|
0.070 | PosttranslationalModification | disease | BEFREE | Our results suggest that reduced expression of E-cadherin is associated with promoter methylation of E-cadherin gene, in addition to providing evidence for the aberrant nuclear localization of E-cadherin in EOC. | 23605324 | 2013 | ||||
|
0.070 | GeneticVariation | disease | BEFREE | There was no significant difference in genotype distribution of the -160C/A and -347G/GA SNPs in the E-cadherin gene promoter region between ovarian cancer patients and controls, but haplotype -160A/-347GA relative to haplotype -160C/-347G was 48.6 (95% CI=2.9-806.2) for epithelial ovarian cancer risk. | 18035404 | 2008 | ||||
|
0.070 | PosttranslationalModification | disease | BEFREE | This study assessed the immuno-expression of E-cadherin and methylation of CDH1 and correlated them with clinical features in primary epithelial ovarian cancer. | 16826427 | 2006 |