Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Inclusion criteria were: age between 18 and 70 years old, diagnosis of epithelial ovarian cancer, optimal primary surgery (residual tumor <1 cm), and normal CA125 at initial diagnosis. 30992329 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Chemotherapy resistance, preoperative CA125 and AFR were independent risk factors for PFS in advanced EOC patients. 31533857 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE In postmenopausal women, sensitivity, specificity, and accuracy were comparable between CA 125 alone and ROMA using either reference cut-off values or optimum cut-off values.ROMA showed better diagnostic performance in differentiating EOC from benign adnexal tumors among premenopausal women. 31708114 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 AlteredExpression disease BEFREE <b>Materials and Methods:</b> We collected EOC samples from 204 patients and examined tumor SIK3 expression by immunohistochemistry (IHC) and CA125 expression in tumors and serum. 31762812 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Heat shock protein 27 (HSP27) may take part in the epithelial ovarian cancer (EOC) malignant process because it is elevated in the serum of EOC patients, suggesting that HSP27 may serve as an EOC biomarker to complement the standard serum carbohydrate antigen 125 (CA125) test. 30502327 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 AlteredExpression disease BEFREE To investigate the prognostic value of serum cancer antigen 125 (CA125) levels during chemotherapy in relapsed epithelial ovarian cancer (EOC) and to identify cut-off values that distinguish patients who relapse beyond 12 months from those who relapse within 12 months. 30687999 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Our study indicates that CYFRA21-1 acts as a good complementary diagnostic biomarker and may be superior to CA125 as a prognostic indicator in EOC. 31767040 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE (3) Univariate and multivariate analyses showed that tumor size, tumor grade, tumor stage, plasma fibrinogen, serum albumin, FA score and tumor marker CA125 were statistically correlated with OS of EOC patients after surgery (<i>P</i><0.05). 31616185 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 AlteredExpression disease BEFREE This study intended to assess the prognostic value of pretreatment PLT count and CA125 level in FIGO stage IV EOC. 31362750 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE This external validation study was conducted to assess the performance of the preoperative plasma tumor markers HE4 and CA125 optimal cut-offs to predict cancer mortality in women with epithelial ovarian cancer (EOC). 31220149 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE In conclusion, the selected SPs in combination with CA125 show profound promise for discriminating EOCs from BOTs and for predicting the progression after surgery, which provides invaluable information for clinicians in the precision diagnosis and treatment of EOC. 30114318 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE MUC16 is a critical inducer of the proliferation and migration of EOC cells and the CTD of MUC16 plays an important role during this process. 30795761 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE CPH-I and HE4 Are More Favorable Than CA125 in Differentiating Borderline Ovarian Tumors from Epithelial Ovarian Cancer at Early Stages. 31737130 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE In previous work, we demonstrated that antennarity, fucosylation, and sialylation increased in EOC patients and built a glycan-based score that was able to diagnose EOC better than CA125, the routine diagnostic marker, does. 31110965 2019
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Both proteins were shed by all EOC subtypes tumors in short term organ culture at more consistent levels than CA125, supporting their potential as pan-subtype serum and tissue biomarkers. 30282979 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Clinical study of a CT evaluation model combined with serum CA125 in predicting the treatment of newly diagnosed advanced epithelial ovarian cancer. 29914567 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types.<b>Impact:</b> Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC. 29661801 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Cancer antigen 125 (CA125) is frequently used in the routine monitoring of patients with epithelial ovarian cancer (EOC). 29619933 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE CA125 is a transmembrane mucin that contributes to the progression of epithelial ovarian cancer. 29102541 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE Ferritin was superior to CA125 in discrimination early EOC (p = 0.002), but in advanced stages, CA125 was superior (p = 0.026). 29452533 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE In the differentiation of stage I FIGO malignancies and epithelial ovarian cancer from nonmalignant pathologies, the AUC of HE4 and ROMA was higher than that of CA125. 29849823 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE This study aims to examine circulating tumor cells (CTCs) in epithelial ovarian cancer (EOC) patients to evaluate their clinical significance in comparison to the existing biomarker CA125. 30092594 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 AlteredExpression disease BEFREE On multivariate logistic regression analysis, age (odds ratio [OR] = 4.14, <i>P</i> < 0.001), CA125 levels (OR = 9.87, <i>P</i> < 0.001), NLR (OR = 1.76, <i>P</i> = 0.049), PLR (OR = 2.41, <i>P</i> = 0.004), and LMR (OR = 0.51, <i>P</i> = 0.024) were found to significantly predict the presence of EOC. 29675097 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE GDF15 predict platinum response during first-line chemotherapy and can act as a complementary diagnostic serum biomarker with CA125 in epithelial ovarian cancer. 29580231 2018
Entrez Id: 94025
Gene Symbol: MUC16
MUC16
0.300 Biomarker disease BEFREE The changes of serum CA125 after neoadjuvant chemotherapy might predict optimal interval debulking surgery in patients with advanced epithelial ovarian cancer. 29702068 2018