Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker phenotype BEFREE Numerous agents target VEGF-mediated signaling, yet resistance and progressive disease still persists. 30572736 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression phenotype BEFREE IHC and irGEP revealed that pretreatment immune activity-including expression of immune checkpoint molecules-for CUP was similar to that for ICI-responsive malignancies (antitumor immune cell signatures: CUP versus PD, P = 0.002-0.067; CUP versus non-PD, P = 0.591-0.999), although VEGFA expression was associated with suppression of antitumor immunity in CUP (P = 0.008, false discovery rate = 0.010). 31519206 2019
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker phenotype BEFREE Patients with progressive disease showed greater basal serum VEGFA and ovarian VEGFA/BMI1 pathway protein expression relative to patients with stable disease and responsive disease (P < 0.05). 30059681 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker phenotype BEFREE Tie2 trajectories were independently associated with pre-treatment tumor vascular characteristics, tumor response, progression free survival (HR for progression = 3.01, p = 0.00014; median PFS 248 vs. 348 days p = 0.0008) and the modeling of progressive disease (p < 0.0001), suggesting that Tie2 should be monitored clinically to optimize VEGF inhibitor use. 30405103 2018
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression phenotype BEFREE i) Serum VEGF levels were higher in patients with progressive disease than those in patients with a partial response or stable disease. ii) VEGF levels were higher in patients with alcoholic LC than those in patients with hepatitis C-related or hepatitis B-related LC. iii) VEGF levels were higher in stage IVB patients than those in patients with stage III or IVA disease. iv) VEGF levels were significantly higher in patients with giant or confluent multinodular tumors than those in patients with multiple discrete nodules. v) Serum VEGF levels were higher in patients with vascular invasion than in patients without vascular invasion. 25862879 2015
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression phenotype BEFREE Blood levels of MUC1 and VEGF mRNA at B0 and at B4w were significantly higher in patients with progressive disease than in those with partial response and stable disease. 25410981 2014
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression phenotype BEFREE Patients with tumors responding to anti-VEGF therapy had lower levels of Dll4 than patients with stable or progressive disease. 21795478 2011
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker phenotype BEFREE When treated with VEGF-targeted therapy, 3 patients achieved a partial response, 7 patients had stable disease, and 5 patients developed progressive disease. 20665500 2010
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression phenotype BEFREE Patients with partial remission or stable disease had significantly lower levels of plasma VEGF than did patients with progressive disease, both at baseline (p=0.0341) and after 2 cycles of chemotherapy (p=0.0265). 19596939 2009
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker phenotype BEFREE Vascular endothelial growth factor (VEGF) blockade has been validated clinically as a treatment for human cancers, yet virtually all patients eventually develop progressive disease during therapy. 18234958 2008
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 Biomarker phenotype BEFREE Thus, in human DN, a decrease of VEGF-A, rather than the reported increase as described in some rodent models, may contribute to the progressive disease. 17475821 2007
Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
0.100 AlteredExpression phenotype BEFREE Clinically active MGN is associated with diminished expression of VEGF protein and mRNA, mainly in podocytes, and expression remains depressed in persistently active and/or progressive disease. 14655184 2003