Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE In addition, we show that YAP<sup>S127A</sup>-transduction of the human MDA-MB-231 breast cancer cell line (that carry a similar KRAS mutation) enhances their metastatic activity in vivo. 31772328 2020
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE KRAS G12D point mutation plays an important role in the incidence of non-small-cell lung cancer (NSCLC) as well as colorectal cancer, pancreatic cancer and breast cancer. 30876538 2019
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 AlteredExpression disease BEFREE Treatment of breast cancer cells with chlorhexidine decreases KRAS protein levels, while a KRAS gene transiently expressed by a promoter lacking a G4 is not affected. 29481610 2018
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE BRAF, KRAS and PIK3CA Mutation and Sensitivity to Trastuzumab in Breast Cancer Cell Line Model 28843257 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE MicroRNA-134 targets KRAS to suppress breast cancer cell proliferation, migration and invasion. 28454346 2017
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE In this study, we investigate the correlation among poorly differentiated carcinoma, epithelial to mesenchymal transition (EMT) phenomenon, and expression of NF-kB, Sonic Hedgehog (SHH), K-RAS, and PTX3 in breast cancer in 100 breast biopsies. 26563370 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE We report that mutations in both PIK3CA and KRAS are required for the greatest aspirin sensitivity in breast cancer, and that the GSK3β protein was hyperphosphorylated in aspirin-treated double knockin cells, but not in other clones/treatments. 26915040 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. 25940428 2016
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE In this study, we conducted sequence analysis of PIK3CA, BRAF, and KRAS and determined relationships with the occurrence of breast cancer in women from Qinghai. 26600545 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Finally, hormone replacement therapy (HRT) discontinuation in KRAS-variant patients was associated with a diagnosis of triple negative BC (P < 0.001). 25961464 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 AlteredExpression disease BEFREE Interestingly, silencing of SAF-1 expression in breast cancer cells by SAF-1-specific short hairpin RNAs (shRNAs) significantly reduced H-Ras and K-Ras mRNA level. 25449683 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE The present study was conducted to test the hypothesis that K-RAS activation is involved in breast cancer risk of south Indian population. 25921169 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE We examined the expression of β III-tubulin, thymidylate synthase, breast cancer susceptibility gene 1 and ribonucleotide reductase M1 (RRM1); identified mutations in epidermal growth factor receptor (EGFR), KRAS, BRAF and HER2; and detected ALK, ROS1 and RET rearrangements. 25257380 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE The genes of MTUS1, CD44, CCNB1, CCND2 and KRAS with specific SNP loci may be used as biomarkers for diagnosis of breast cancer. 25408372 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Taken together, this study demonstrates that KRAS is a critical regulator for the metastatic behavior associated with mesenchymal features of breast cancer cells, implicating a novel therapeutic target for basal-type breast cancer. 25633745 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Our findings provide clues regarding the role of miR-200c as a tumor suppressor in breast cancer through the inhibition of KRAS translation both in vitro and in vivo. miR-200c could be a potential therapeutic target in breast cancer. 26392416 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE We observed no statistically significant association between BC risk and the let-7a KRAS rs712 polymorphism (GT vs GG, OR = 0.98, 95%CI = 0.66-1.46; TT vs GG, OR = 0.78, 95%CI = 0.28-2.21). 26681038 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE AKT1, KRAS and PIK3CA mutations and PTEN loss all exist in women with breast cancer in the mainland China. 25816324 2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 AlteredExpression disease BEFREE We show that KRAS is a predicted target of miR-200c and that the protein expression of KRAS inversely correlates with the miR-200c expression in a panel of human breast cancer cell lines. 24368337 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Androgen-induced AR activating signal upregulates let-7a that targets CMYC and KRAS and contributes to ER-, PR-, AR+ breast cancer pathogenesis. 24172884 2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE The incorporation of molecular profiling into routine clinical practice has already been adopted in some tumor types, such as human epidermal growth factor receptor 2 (HER2) testing in breast cancer and KRAS genotyping in colorectal cancer, providing a guide to treatment selection that is not afforded by histopathologic diagnosis alone. 23589555 2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE We aimed to evaluate whether the hormone receptor expression, HER2 and MYC genes and their protein status, and KRAS codon 12 mutations may be prognostic or predictive biomarkers of breast cancer. 23555992 2013
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Biomarkers such as HER2 for breast cancer or EGFR mutation for lung cancer and KRAS mutation in colon cancer have contributed to identify a patient population that might show a good and bad treatment response, respectively. 21652149 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 Biomarker disease BEFREE Investigating the impact of Ido1 gene disruption in mouse models of oncogenic KRAS-induced lung carcinoma and breast carcinoma-derived pulmonary metastasis, we have found that IDO deficiency resulted in reduced lung tumor burden and improved survival in both models. 22822050 2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
0.700 GeneticVariation disease BEFREE Associations between the KRAS genotype and breast cancer or breast tumor characteristics were assessed using chi-square test and logistic regression models. 22436609 2012