Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE The variants in TP53, BRCA1, and BRCA2 are likely to have contributed to the early onset lung cancer in the respective patients (3/21 or 14%). 30032850 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Our results show that LUDLU-1 lacks the mutational signature that has been previously associated with tobacco exposure in other lung cancer subtypes, and suggests that DNA-repair efficiency is adversely affected; LUDLU-1 contains somatic mutations in TP53 and BRCA2, allelic imbalance in the expression of two cancer-associated BRCA1 germline polymorphisms and reduced transcription of a potentially endogenous PARP2 inhibitor. 24244370 2013
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 AlteredExpression disease BEFREE Hsa_circ_0046264 and BRCA2 were down-regulated in lung cancer tissues while miR-1245 was up-regulated. 29891014 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE We did not identify increased frequencies of oesophageal, pancreatic or lung cancer in families with just BRCA2 c.9976A>T using person-years at risk analysis. 26041759 2015
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Association of allelic imbalance at locus D13S171 (BRCA2) and p53 alterations with tumor kinetics and chromosomal instability (aneuploidy) in nonsmall cell lung carcinoma. 11064350 2000
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 Biomarker disease BEFREE Antisense-mediated reduction of IDO, alone and (in a synthetic lethal approach) in combination with antisense to the DNA repair protein BRCA2 sensitizes human lung cancer cells to olaparib and cisplatin. 24784564 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE We identified large-effect genome-wide associations for squamous lung cancer with the rare variants BRCA2 p.Lys3326X (rs11571833, odds ratio (OR) = 2.47, P = 4.74 × 10(-20)) and CHEK2 rs17879961" genes_norm="11200;8626">p.Ile157Thr (rs17879961, OR = 0.38, P = 1.27 × 10(-13)). 24880342 2014
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Previous studies have shown that two rare variants, rs11571833 in BRCA2 and rs17879961 in CHEK2 were associated with lung cancer. 27632928 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE Although BRCA2 is important in DNA repair, few data are available on the association between BRCA2 polymorphisms and lung cancer in women. 26979245 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease BEFREE We selected eight genes, ATM serine/threonine kinase gene (ATM), BRCA2, DNA repair associated gene (BRCA2), checkpoint kinase 2 gene (CHEK2), EGFR, parkin RBR E3 ubiquitin protein ligase gene (PARK2), telomerase reverse transcriptase gene (TERT), tumor protein p53 gene (TP53), and Yes associated protein 1 gene (YAP1), on the basis of prior anecdotal association with lung cancer or genome-wide association studies. 28843361 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 AlteredExpression disease BEFREE Anchorage-dependent growth after reexpression of these genes was examined in a lung cancer cell line that originally lacked BRCA1 and BRCA2 expression. 17289874 2007
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 CausalMutation disease CGI
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GenomicAlterations disease CGI
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease GWASCAT Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes. 28604730 2017
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease GWASCAT Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations. 27197191 2016
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.500 GeneticVariation disease GWASCAT Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. 24880342 2014