Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE In CRC tumor tissues, CCR7 was significantly over-expressed compared with paired normal tissues (<i>P</i> < 0.001), and correlated with the infiltration depth (<i>P</i> = 0.03) and the regional lymph node metastasis (<i>P</i> = 0.006). 31815051 2019
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 Biomarker disease BEFREE Our results suggest that TNF-α leads to the induction of CCR7 expression and that the CCL21/CCR7 axis might increase the metastatic potential of prostate cancer cells in lymph node metastasis. 29575464 2018
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE The pooled relative risks indicated CCR7 expression was significantly associated with deeper tumor invasion [0.61, 95 % confidence interval (CI) 0.45-0.84, p = 0.003], advanced stage (0.47, 95 % CI 0.32-0.69, p < 0.001), vascular invasion (2.12, 95 % CI 1.20-3.73, p = 0.009), lymph node metastasis (2.00, 95 % CI 1.48-2.70, p < 0.001), and lymphatic invasion (1.98, 95 % CI 1.43-2.72, p < 0.001) but not with age, tumor size, and histological type. 26984468 2017
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 Biomarker disease BEFREE For example, CCL21 (CC chemokine ligand 21) and CCL19 (CC chemokine ligand 19) recruit antigen-presenting dendritic cells and naïve T-cells to the lymph nodes and are thought to play a role in lymph node metastasis of CCR7 (CC chemokine receptor 7)-expressing cancer cells. 28841151 2017
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Clinical case studies show that higher expression of CCR7 in lung adenocarcinoma tissues was associated with a higher lymph node metastasis. 28819407 2017
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Moreover, a possible correlation of CCR7 high expression and patients' baseline and post-administration lymph node metastasis was found. 28114889 2017
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Our results indicated that elevated CCR7 expression as a marker for increased lymph node metastasis, in addition to serve as an independent prognostic indicator for better overall survival in triple negative breast cancer patients. 28930757 2017
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Based on these results, we conclude that activation of the CCL21/CCR7 chemoaxis promotes lymph node metastasis of UBC in at least two ways. 28534984 2017
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Higher expression of CCR7 was associated with American Joint Committee on Cancer (AJCC) staging and lymph node metastasis. 27009073 2016
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 Biomarker disease BEFREE Our findings show that the molecular cues secreted by TALs alone or in combination with CCR7 may emerge as future therapeutic targets for lymph node metastasis in breast cancer patients. 25327843 2015
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 Biomarker disease BEFREE CCL21-CCR7 promotes the lymph node metastasis of esophageal squamous cell carcinoma by up-regulating MUC1. 26667143 2015
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE In this work, CCR7 and CrkL over-expressed in EOC tissues and cell lines and correlated with FIGO stage and lymph node metastasis. 25636509 2015
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE The immunohistochemistry results also showed that the phosphorylation of STAT3 was correlated with CCR7 expression in SCCHN, and CCR7 and STAT3 phosphorylation were all associated with lymph node metastasis. 25405202 2014
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE These results demonstrated the significant clinicopathological relationship and functional causality between CCR7 expression and lymph node metastasis in ESCC patients. 24766770 2014
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE By immunohistolochemistry, high expressions of CCR7, Slug and N-cadherin were seen in 60, 65, and 76.67 % of tumors, respectively, and significantly associated with lymph node metastases as well as clinical pathological stage. 25142946 2014
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Our data showed CCR7 expression was observed in 22 cases of tissues and closely associated with lymph node metastasis and FIGO stage (III + IV). 25168373 2014
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Negative Dicer 1 protein and let-7a miRNA expression and positive CCR7 protein expression significantly correlated with lymph node metastasis, depth of invasion, high clinical TNM stage, and larger tumor size. 23519840 2013
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE High CCR7 expression in gastric cancer cells was significantly associated with poor overall survival (OS) (P = 0.010) and lymph node metastasis (P = 0.009), and was an independent factor for worse OS (P = 0.023) by multivariate analysis. 24040244 2013
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis. 22976543 2013
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Immunohistochemical assay also showed that CCR7 and PKCα were highly expressed in SCCHN and correlated with each other, which was significantly related to lymph node metastasis and clinical stage. 21735098 2011
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 Biomarker disease BEFREE CCR7 and CXCR4 mRNAs were significantly higher in HNSCC tissues than in non-neoplastic tissues (p<0.05, respectively) and correlated with lymph node metastasis (p<0.05, respectively). 20036791 2010
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE Levels of CCR7 and CXCR4 expression were high in 26.9% (25/93) and in 32.3% (30/93), respectively of tumor cells and the levels significantly correlated with lymph node metastasis according to H&E staining (P=0.0212 and P=0.0115, respectively). 19513547 2009
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE A significant correlation was detected between CCR7-positive expression and lymph node metastasis. 18544997 2008
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 Biomarker disease BEFREE High-intensity IHC staining for CXCR4 was associated with larger tumor size (P = .02), while PTCs exhibiting ETE, ALI, or lymph node metastasis showed higher-intensity IHC staining for CCR7 than those without (P = .01, .03, and .01, respectively). 18696160 2008
Entrez Id: 1236
Gene Symbol: CCR7
CCR7
0.100 AlteredExpression disease BEFREE The expression of CCR7 and vigorous responses to its ligand CCL21 potentially account for lymph node metastasis of a human NSCLC line Lu-99. 17487412 2007