Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE Moreover, the results indicated that low nm23 expression was significantly correlated with the lymph node metastasis (P = 0.002). 30389538 2018
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE The protein expression of Nm23-H1 was correlated with lymph node metastases (χ<sup>2</sup>=11.847; P=0.001) and pathological patterns (χ<sup>2</sup>=6.911; P=0.032). 28123532 2017
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE In addition, high NME1 protein levels are correlated with negative lymph node metastasis in gastric cancer. 22903495 2012
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE NM23-H1 was associated with less lymph node metastasis in the ER-positive pre-menopausal group (r = -0.237, p < 0.05). 21913743 2011
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE The upregulation of prohibitin or the downregulation of 14-3-3sigma and nm23-H1 proteins was significantly associated with the proliferation, invasion depth, and lymph node metastasis of ESCC. 19664078 2010
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE Our data demonstrated that the expression of nm23-H1 was negatively correlated with tumor stage and grade and lymph node metastasis, whereas the expression of AKT/pAKT was positively correlated with these clinic factors. 18949358 2008
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE The intensity of nm23 staining in the tumor cells was not significantly correlated with depth of tumor infiltration (T-stage), lymph node metastasis (N-stage), distant metastasis (M-stage), UICC-stage, or prognosis. 17695492 2007
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE To further explore the tumor metastasis suppressor function of nm-23 in HNSCC, we studied high-stage laryngeal carcinomas, tumors with and without cervical lymph node metastasis for nm-23 protein expression and loss of heterozygosity of the gene locus. 16531762 2006
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE However, the expression of nm23 mRNA was correlated negatively to the lymph node metastasis of gastric and colorectal adenocarcinoma (r = -0.49, P<0.01; r = -4.93, P<0.01). 16425351 2005
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE Although no mutation of the E-cadherin and nm23 genes was detected, the results obtained in the present study showed that reduction of E-cadherin and nm23 mRNA expression remarkably correlated with low histological differentiation, increasing stage as well as lymph node metastases (P<0.05). 15777972 2005
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE Despite their different mechanisms of action, heparanase, CD44v6 and nm23 may play important roles in the invasive infiltration and lymph node metastasis in gastric carcinomas. 15040016 2004
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE In patients at the early T stage, decreased nm23 expression was associated with increased incidence of lymph node metastasis (P=0.004) and indicated poor survival (P=0.014). 15150613 2004
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE Survival of nm23-H1 positive group was statistically superior to nm23-H1 negative group (P < 0.0001) By multivariate survival analysis, tumor stage, the number of lymph node metastasis and expression of nm23-H1 were the independent prognostic factors for ESCC patients. 15296908 2004
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE The nm23-H1 (+)/E-cadherin (+) coexpression profile was observed in 31% and was significantly related to the absence of lymph node metastases in 31% and stages Astler-Coller B1 and B2 in 29% of the carcinomas examined. 12684753 2003
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE Univariate analyses identified nm23 (p < 0.05), chromosome 17 aberrations (p < 0.05), tumor size (p < 0.01), depth of invasion (p < 0.0001), lymph node metastasis (P < 0.001), hepatic metastasis (p < 0.01), peritoneal dissemination (p < 0.01), and lymphatic invasion (p < 0.01) as significant prognostic factors. 12512918 2002
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE Lymph node metastasis was found at a significantly higher incidence in the nm23(+/-/-) cases (18/27, 66.7%) than in the nm23(+) cases (4/17, 23.5%) (p>0.001). 11744991 2002
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE Reduced expression of nm23 gene product was observed in patients with positive lymph node metastasis (P = 0.0006, chi(2)). 10629490 2000
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 Biomarker disease BEFREE The NM23-H1 positive group showed lower frequency of lymph node metastasis, and a better grading than the NM23-H1 negative group supporting the role of NM23-H1 as metastasis suppressor factor which may be useful for predicting tumor metastasis in OSCC. 10373649 1999
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE Reduced nm23 expression in breast carcinoma has been found to correlate with axillary lymph node metastases, high grade tumors, and shorter survival. 9570214 1998
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE Expression of nm23-H1 protein indicated favorable prognosis, suggesting that the absence of nm23-H1 protein expression was significantly associated with lymph-node metastasis, recurrence and distant metastasis in NPC. 9842967 1998
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE This observation suggested that focally positive/negative nm23 expression can be a predictor of lymph node metastasis of invasive ductal breast carcinoma. 9824622 1998
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE NM23.H2 was always more highly expressed than NM23.H1, and reduced expression of NM23.H1 but not NM23.H2 was concordant with the presence of lymph node metastasis or local invasiveness of the primary tumor. 9036878 1997
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE The membranous nm23 expression revealed negative correlation with lymphatic invasion(P < 0.02), lymph node metastasis(P < 0.01) and distant metastasis(P < 0.02). 8924224 1995
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE A significant relationship between nm23-H1 mRNA expression and lymph node metastasis was observed in high-grade tumors, which are intrinsically more invasive than are low-grade tumors. 7780979 1995
Entrez Id: 4830
Gene Symbol: NME1
NME1
0.100 AlteredExpression disease BEFREE The time from biopsy of the primary MM to the appearance of the first lymph node metastasis also showed a positive correlation with the nm23 mRNA level in this metastasis. 7981081 1994