Gene: CDH1 ×
Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 CausalMutation disease CLINVAR
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease CLINVAR
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 CausalMutation disease CGI
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease UNIPROT
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 Biomarker disease BEFREE 59 GCs, 59 first degree relatives (FDRs) of GC, 20 autoimmune metaplastic atrophic gastritis (AMAGs) and 52 blood donors (BDs) were analyzed for CDH1 by direct sequencing, structural modelling and bioinformatics. 24204729 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE Gastric cancer (GC) is considered to be one of the leading cancers in East Asians, and mutations in the CDH1 gene and the reduced expression of E-cadherin are the most frequent genetic alterations in gastric cancer. 23435907 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 PosttranslationalModification disease BEFREE E-cadherin gene (CDH1) promoter methylation as the second hit in sporadic diffuse gastric carcinoma. 11313896 2001
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 c-160a promotor polymorphism is not associated with risk of stomach cancer. 12209998 2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE E-cadherin gene variants in gastric cancer families whose probands are diagnosed with diffuse gastric cancer. 12216071 2002
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 gene germline mutation is common in many types of carcinoma, and occurs very frequent in hereditary gastric carcinoma (HGC) patients and their families. 15457549 2004
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE E-cadherin gene C-160A promoter polymorphism may not play a major role in the etiology of non-cardia gastric cancer in Chinese population. 15609397 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 Biomarker disease BEFREE CDH1 associated gastric cancer: a report of a family and review of the literature. 15780560 2005
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 PosttranslationalModification disease BEFREE CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion. 16531765 2006
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 mutations in individuals from families with HDGC are associated with gastric cancer in a highly penetrant fashion. 17522512 2007
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 PosttranslationalModification disease BEFREE E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. 18249489 2008
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 C-160A promoter polymorphism and gastric cancer risk. 19077564 2009
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 -160 -AA genotype was associated with an increased risk of GC (OR = 3.6, 95% CI: 1.1-11.8) (P = 0.03). 20632448 2010
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 Biomarker disease BEFREE E-cadherin genetic screening and clinico-pathologic characteristics of early onset gastric cancer. 21106365 2011
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 mutation carriers have a strongly increased risk of developing gastric cancer (GC) and lobular breast cancer (LBC). 22020549 2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 mutation testing in families with a history of gastric cancer and prophylactic gastrectomy in mutation-positive patients are recommended for the management of HDGC. 22160243 2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 PosttranslationalModification disease BEFREE CDH1 methylation in preoperative peritoneal washes is an independent prognostic factor for gastric cancer. 22514028 2012
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 somatic alterations were found in approximately 30% of all patients with GC. 23341533 2013
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer. 25981591 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 AlteredExpression disease BEFREE CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with HOTAIR (r(2)=0.154, P=0.0354). 26136075 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1 		0.700 GeneticVariation disease BEFREE CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer. 30642281 2019