Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer. 28460635 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR. 29443099 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Digital PCR identifies changes in CDH1 (E-cadherin) transcription pattern in intestinal-type gastric cancer. 27861150 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE A prospective gastric cancer database identified 41 patients with CDH1 mutation who underwent total gastrectomy during 2005 to 2015. 27759617 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. 28024868 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with HOTAIR (r(2)=0.154, P=0.0354). 26136075 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer. 26334097 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). 25979631 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The aim of this study was to find the putative gastric cancer predisposing gene defect in a family with HDGC that had previously been tested negative for mutations in CDH1. 25576241 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review. 25926721 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Carriers of CDH1 mutations are at risk for a highly penetrant, aggressive and early-onset diffuse-type gastric cancer, and these individuals are usually offered prophylactic total gastrectomy. 26363540 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE CDH1 gene mutations have been found to be associated with diffuse type gastric cancer and invasive lobular carcinoma (ILC) of the breast. 26358115 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis. 25599647 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Epigenetic regulation of CDH1 exon 8 alternative splicing in gastric cancer. 26674321 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 PosttranslationalModification disease BEFREE Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer. 25874772 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE For patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric cancer. 26443527 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The methylation of p16 (17.9 vs. 0 %, P = 0.002), CDH1 (20.9 vs. 2.2 %, P < 0.001), MGMT (17.9 vs. 0 %, P = 0.052), and hMLH1 (14.9 vs. 2.2 %, P = 0.024) was more common in gastric cancer tissues (n = 134) than in non-tumor tissues (n = 46). 24816738 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Probands from two Danish families with gastric cancer and a history suggesting HDGC were screened for CDH1 gene mutations. 24389957 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Presymptomatic identification of CDH1 germline mutation in a healthy korean individual with family history of gastric cancer. 25187893 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. 23812922 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE In this report, we describe a germline CDH1 c.48 G>C variant found in a 21 year old woman and her living great uncle, who were both diagnosed with gastric cancer and belong to a family with high incidence of this type of cancer. 25771876 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Patients with gastric cancer and germline CDH1 mutations had shorter survival times than patients who met the HDGC criteria but did not have CDH1 mutations. 26072394 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE MiR-145 inhibits invasion of gastric cancer cells not only by down-regulating cytoplasmic CTNND1 expression but also by inducing the translocation of CTNND1 and E-cadherin from the cytoplasm to the cell membrane through down-regulating N-cadherin. 25470111 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The risk of development of gastric cancer is high in families affected b-y these syndromes, but only hereditary diffuse gastric cancer is genetically explained (caused by germline alterations of CDH1, which encodes E-cadherin). 25638682 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Other genetic variants recently evaluated in large meta-analyses and associated with gastric cancer risk were also analyzed in a few studies [e.g., prostate stem cell antigen (PSCA), CDH1, Survivin]. 24782603 2015