Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations. 31077828 2020
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE Ectopic expression of circFNDC3B reduced the level of E-cadherin protein to promote the epithelial-mesenchymal transition in GC. 30963578 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE We detected the epidermal growth factor receptor L858R, MSH2 R929* and telomerase reverse transcriptase amplification in the lung cancer specimen; CDH1 c.1320+1G>T mutation in the gastric cancer (GC) specimen; and MLH1 c.1896+5G>A germline mutation in the lung and GC specimens by 450 cancer-related gene mutations detection using next-generation sequencing technology. 31207149 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE CDH1 somatic alterations in Mexican patients with diffuse and mixed sporadic gastric cancer. 30642281 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The cumulative incidence of gastric cancer for individuals with pathogenic variants in CDH1 is significantly lower than previously described. 31246251 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Our results demonstrate that germline CDH1 mutations are a significant contributor to the high frequency of diffuse gastric cancer in New Zealand Māori. 29589180 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer. 30168144 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 PosttranslationalModification disease BEFREE CDH1 hypermethylation status was found to be associated with advancement of disease, distant organ metastases and lymph node invasion in Gastric cancer patients. 30989488 2019
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE CDH1a, a non-canonical transcript of the CDH1 gene, has been found to be expressed in some gastric cancer (GC) cell lines, whereas it is absent in normal gastric mucosa. 29443099 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Mutations in the CDH1 gene are linked both to diffuse gastric cancer and invasive lobular carcinoma (ILC). 28993866 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE The results revealed that CDH1, cyclooxygenase-2 and matrix metalloproteinase genes had significantly higher expression levels, whereas the expression levels of dermatopontin and transforming growth factor β receptor 2 were decreased in GC samples. 29434905 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE We identified a new truncating germline mutation (p.Asp538Thrfs*19) in exon 11 of the CDH1 gene in a 41-year-old male with a diffuse gastric cancer. 29131691 2018
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 AlteredExpression disease BEFREE For the first time, we evaluated by digital PCR the expression of CDH1 and CDH1a transcripts in cancer and normal tissue samples from 32 patients with intestinal-type gastric cancer. 27861150 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Female predominance in early-onset gastric cancer may be related to relatively high rates of somatic CDH1 and TGFBR1 mutations in this population. 28522256 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 PosttranslationalModification disease BEFREE In addition, methylation of the CDH1 gene in AM may be a surrogate of GC. 29042646 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 Biomarker disease BEFREE It is implied that TRERNA1/CDH1 is a new potential target for GC therapy. 28918030 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE HDGC, which is mainly caused by germline mutations in the E-cadherin gene (CDH1), renders a lifetime risk of gastric cancer of up to 70%, prompting a recommendation for prophylactic total gastrectomy. 27759617 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE To identify genetic variants that affect risk for gastric cancer, we collected blood samples from 28 patients with hereditary diffuse gastric cancer (HDGC) not associated with mutations in CDH1 and performed whole-exome sequence analysis. 28024868 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The <i>CDH1</i> gene, coding for the E-cadherin protein, is linked to gastric cancer (GC) susceptibility and tumor invasion. 29295527 2017
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE This study was aimed to analyse the hypermethylation status of the E-Cadherin (CDH1) gene promoter in GCs in the ethnic Kashmiri population. 27356686 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Germline E-cadherin/CDH1 mutations have been identified in families with an autosomal dominant inherited predisposition to diffuse gastric cancer. 27899187 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE Furthermore, the CDH1 c.1679C>G (p.T560R) variant segregated with gastric cancer in all three family members affected with gastric cancer in this family. 27880784 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results. 27706737 2016
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer. 25981591 2015
Entrez Id: 999
Gene Symbol: CDH1
CDH1
0.700 GeneticVariation disease BEFREE The risk of development of gastric cancer is high in families affected b-y these syndromes, but only hereditary diffuse gastric cancer is genetically explained (caused by germline alterations of CDH1, which encodes E-cadherin). 25638682 2015