Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 Biomarker disease BEFREE ATM participates in the regulation of viability and cell cycle via ellipticine in bladder cancer. 28138703 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 Biomarker disease BEFREE Taken together, these findings suggested that ATM may be an effective target in the radiotherapy of patients with DAB2IP-deficient BCa. 28586028 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 Biomarker disease BEFREE We hypothesize that this BBN-induced RGS6 loss represents a critical hit in UBC as it irrevocably impairs the anti-proliferative actions of the ATM/p53 and RASSF1A pathways. 27713144 2016
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 Biomarker disease BEFREE In contrast, a bladder cancer cell line cotreated with ATM and replication inhibitors progressed more slowly through S phase and showed a marked increase in apoptosis. 25043304 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 Biomarker disease BEFREE Taken together, our findings established a role for ATDC as a robust pathogenic driver of bladder cancer development, identified downstream effector pathways, and implicated ATDC as a candidate biomarker and therapeutic target. 26471361 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 Biomarker disease BEFREE The ATM inhibitor KU55933 sensitizes radioresistant bladder cancer cells with DAB2IP gene defect. 25585815 2015
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 AlteredExpression disease BEFREE Pretreatment with genistein sensitized BDEC and bladder cancer cell lines to HCPT-induced DNA damage by the synergistic activation of ataxia telangiectasia mutated (ATM) kinase. 23365634 2013
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 GeneticVariation disease BEFREE We examined the associations between bladder cancer and 7 polymorphisms from 5 genes involved in the maintenance of genetic stability (MMR: MLH1-93G>A; BER: XRCC1--77T>C and Arg399Gln; NER:XPC Lys939Gln and PAT +/-; DSBR:ATM G5557A and XRCC7 G6721T) in 302 incident bladder cancer cases and 311 hospital controls. 22927776 2012
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 GeneticVariation disease BEFREE Depletion of ATM from two cancer cell lines, including the p53-mutant UM-UC-3 bladder cancer line, rendered the cells largely unresponsive to MT-hTer-47A. 18593932 2008
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 CausalMutation disease CGI
Entrez Id: 472
Gene Symbol: ATM
ATM
0.390 GenomicAlterations disease CGI