Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 Biomarker disease BEFREE Treatment of both <i>Tsc2<sup>+/</sup></i><sup>-</sup> mice and a TSC1-null bladder cancer xenograft model with a CDK7 inhibitor showed marked reduction in tumor volume and absence of regrowth in the xenograft model. 31506280 2019
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 Biomarker disease BEFREE Mutation of the co-chaperone Tsc1 in bladder cancer diminishes Hsp90 acetylation and reduces drug sensitivity and selectivity. 31645902 2019
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 GeneticVariation disease BEFREE TSC1/2 mutations also occur in other neoplastic disorders, including lymphangioleiomyomatosis (LAM) and bladder cancer. 29669930 2018
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 Biomarker disease BEFREE Loss of TSC1 function, a crucial negative regulator of mTOR signaling, is a common alteration in bladder cancer. 27225870 2017
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 GeneticVariation disease BEFREE In addition, we observed that bladder cancer cell lines (RT4, UMUC-3, and J82) with homozygous deletion of either TSC1 or PTEN are more sensitive to metformin than those (TEU2, TCCSUP, and HT1376) with wild-type TSC1 and PTEN genes. 26921394 2016
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 GeneticVariation disease BEFREE The TSC1 c. 1907 1908 del (E636fs) mutation in bladder cancer suggests that the location of the mutation is Exon 15 with frequency of TSC1 mutation of 11.7 %. 27352265 2015
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 Biomarker disease BEFREE We used genomic sequencing to examine the involvement of TSC1 in bladder cancer, and signalling pathway analysis and small-molecule screening to identify targeted therapeutic strategies in TSC1 mutant bladder cancer cell lines. 23401075 2013
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 Biomarker disease BEFREE Association of TSC1/hamartin, 14-3-3sigma, and p27 expression with tumor outcomes in patients with pTa/pT1 urothelial bladder carcinoma. 18480009 2008
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 GeneticVariation disease BEFREE We conclude that although TSC1 missense mutations do not play a major role in causation of TSC disease, they represent a significant proportion of somatic loss of function mutations in bladder cancer. 18397877 2008
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 AlteredExpression disease BEFREE Recent data suggest that functional inactivation of TSC proteins might also be involved in the development of other diseases not associated with TSC, such as sporadic bladder cancer, breast cancer, ovarian carcinoma, gall bladder carcinoma, non-small-cell carcinoma of the lung, and Alzheimer's disease. 16713332 2006
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 GeneticVariation disease BEFREE The mutation spectrum of TSC1 in bladder cancer and functional evidence from TSC1 -gene-replacement studies in bladder tumour cells will be presented. 12773163 2003
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 Biomarker disease BEFREE This may indicate that haploinsufficiency for TSC1 can contribute to the development of bladder cancer and, if so, that the LOH of TSC1 observed in >50% of TCCs is biologically significant. 14633685 2003
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 GeneticVariation disease BEFREE The chromosome 9q genes TGFBR1, TSC1, and ZNF189 are rarely mutated in bladder cancer. 11329144 2001
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 GeneticVariation disease BEFREE Mutation of the 9q34 gene TSC1 in sporadic bladder cancer. 10353610 1999
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 CausalMutation disease CGI
Entrez Id: 7248
Gene Symbol: TSC1
TSC1
0.400 GenomicAlterations disease CGI