Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We demonstrated that expression of the fully active G93A Cu,Zn superoxide dismutase mutant in neuroblastoma cells is associated with an increased level of oxidatively modified proteins, in terms of carbonylated residues. 12753090 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We detected this interaction both in spinal cord extracts of mutant SOD1(G93A) transgenic mice and in cultured neuroblastoma cells. 17403032 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 AlteredExpression disease BEFREE Impairment of glutamate transport and increased vulnerability to oxidative stress in neuroblastoma SH-SY5Y cells expressing a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis. 15670639 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE SH-SY5Y neuroblastoma cells transfected with the G93A mutant of SOD1 typical for familial ALS (G93A-SOD1) were more vulnerable to the neurotoxic action of pneumolysin and to the attack of monocytes stimulated by Pam3CSK4 than SH-SY5Y cells transfected with wild-type human SOD1. 17997855 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE In the light of the possibility that different SOD1 entities could be expressed also in other neurodegenerative disorders, as a sort of unifying event with AD and PD, we have investigated amyotrophic lateral sclerosis (ALS) using human neuroblastoma SH-SY5Y cells with mutated SOD1 gene H46R as cellular model. 17987632 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE In this paper, we report a calcineurin-dependent activation of nuclear factor-kappaB (NF-kappaB) induced by the expression of familial amyotrophic lateral sclerosis (fALS)-SOD1s in human neuroblastoma cell lines. 12437573 2002
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Overexpression of a familial mutant form of superoxide dismutase 1 (SOD1) (G93A) in neuroblastoma cells resulted in a similar reduction of IGF-1Rβ protein. 22875931 2012
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE To characterize the cellular response to mitochondrial perturbations at the level of gene expression and alternative pre-mRNA splicing we used splicing-sensitive microarrays to profile human neuroblastoma SH-SY5Y cells treated with paraquat, a neurotoxic herbicide that induces the formation of reactive oxygen species and causes mitochondrial damage in animal models, and SH-SY5Y cells stably expressing the mutant G93A-SOD1 protein, one of the genetic causes of ALS. 21120952 2011
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE In order to investigate the effect of various calcium modulators and the SOD-1 mutation on neuronal death, we tested motoneuron-neuroblastoma hybrid (VSC 4.1) cells constitutively expressing human SOD-1 gene with mutations (A4V, G93A) or wild-type. 12151755 2002
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We report that the expression of mutant G93A copper/zinc superoxide dismutase (SOD1), associated with familial amyotrophic lateral sclerosis, specifically causes a decrease in MTT reduction rate and ATP levels and an increase in both cytosolic and mitochondrial reactive oxygen species (ROS) production in human neuroblastoma SH-SY5Y cells compared to cells overexpressing wild-type SOD1 and untransfected cells. 12901835 2003
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We also detected oligomer formation of L84V SOD1 in L84V SOD1-expressing human neuroblastoma cells. 20816908 2010
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE We have investigated the functional effects of RNAi-mediated silencing of mutant SOD1 in cultured murine neuroblastoma cells. 14981234 2004
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Expression of mutant SOD1 (G37R) resulted in a time and dose-related death of differentiated neuroblastoma cells. 12067230 2002
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE Overexpression of mutated Cu,Zn-SOD in neuroblastoma cells results in cytoskeletal change. 15456693 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE Immunofluorescence and co-immunoprecipitation experiments showed that the 14-3-3ɛ and θ isoforms interact with mutant SOD1 aggregates in the juxtanuclear quality control compartment of N2a neuroblastoma cells. 28666328 2017
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 AlteredExpression disease BEFREE On the contrary, overexpression of mutant SOD1s associated with familial amyotrophic lateral sclerosis (FALS) impairs CN activity both in transfected human neuroblastoma cell lines and in the motor cortex of brain from FALS-transgenic mice. 10899935 2000
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We have investigated the response to oxidative stress in a model system obtained by stable transfection of the human neuroblastoma cell line SH-SY5Y with plasmids directing constitutive expression of either wild-type human Cu,Zn superoxide dismutase or a mutant of this enzyme (H46R) associated with familial amyotrophic lateral sclerosis. 10461909 1999
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE Expression of a Cu,Zn superoxide dismutase typical of familial amyotrophic lateral sclerosis induces mitochondrial alteration and increase of cytosolic Ca2+ concentration in transfected neuroblastoma SH-SY5Y cells. 9315720 1997
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE To understand better the role of these mutations in the pathophysiology of FALS we have compared the pattern of proteins expressed in human neuroblastoma SH-SY5Y cell line with those of cell lines transfected with plasmids expressing the wild-type human SOD1 and the H46R and G93A mutants. 17979159 2007
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE We show that human glioblastoma cells expressing G93A-SOD1 induce activation of caspase-1, release of cytokines, and activation of apoptotic pathways in cocultured human neuroblastoma cells also expressing G93A-SOD1. 15208263 2004
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Here we used an in vitro neuroblastoma cell line transfection system to monitor wild-type and mutant forms of SOD1 fusion proteins containing either a Cherry or an enhanced green fluorescent protein (EGFP) tag. 31336405 2019
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 Biomarker disease BEFREE To assess the biological consequences of superoxide dismutase 1 overproduction within cells, the human superoxide dismutase 1 gene and a human superoxide dismutase 1 cDNA were introduced into mouse L cells and NS20Y neuroblastoma cells. 3334851 1988
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Proteolytic processing characteristic of caspase-1 activation is seen both in spinal cords of transgenic ALS mice and neurally differentiated neuroblastoma (line N2a) cells with SOD1 mutations. 9861044 1998
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 GeneticVariation disease BEFREE Motoneuron-neuroblastoma hybrid (VSC 4.1) cells expressing mutant SOD1, when treated with copper chloride, showed reduced viability and increased levels of endogenous peroxides. 15812313 2005
Entrez Id: 6647
Gene Symbol: SOD1
SOD1
0.100 AlteredExpression disease BEFREE Overexpression of Cu-Zn superoxide dismutase protects neuroblastoma cells against dopamine cytotoxicity accompanied by increase in their glutathione level. 12941444 2003