Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE Here, we investigated the neuroprotective and restorative involvement of the DA DA-JC1 and liraglutide (Lg), a single GLP-1 receptor analogue, in vitro using human neuroblastoma (SH-SY5Y) against oxidative stress induced by oxygen peroxide (H<sub>2</sub>O<sub>2</sub>), and in vivo, in a mouse model of Alzheimer's disease (AD), APP/PS1. 31628935 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.100 AlteredExpression disease BEFREE Using biochemical, molecular, transmission electron microscopy, immunoblotting and immunofluorescence analyses, we studied the protective effects of ligand 1 against Aβ-induced synaptic and mitochondrial toxicities in mouse neuroblastoma (N2a) cells that express mutant APP. 31595293 2020
Entrez Id: 351
Gene Symbol: APP
APP
0.100 AlteredExpression disease BEFREE Increased S1T expression was also observed in human neuroblastoma cells expressing Swedish-mutated β-amyloid precursor protein (βAPP) or treated with Aβ oligomers. 31795302 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 AlteredExpression disease BEFREE Indeed, AHI1 was significantly reduced in mouse neuroblastoma N2a cells expressing human Swedish and Indiana APP (designed as AD model cells) and in 3xTg-AD mouse brain. 31062249 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 GeneticVariation disease BEFREE Here, we show that expression of a phosphomimetic variant of Ser-675 in APP (APP-S675E), in human neuroblastoma SK-N-AS cells, reduces secretion of the soluble APP ectodomain (sAPPα), even though the total plasma membrane level of APP was unchanged compared with APP levels in cells expressing APPwt or APP-S675A. 31604820 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE MLC601 has been shown to modulate amyloid precursor protein (APP) processing in human neuroblastoma cell cultures and increase the levels of soluble APPα. 30723778 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 GeneticVariation disease BEFREE In the present study, we aimed to characterize the link between ER stress and bioenergetics defects under normal condition (human SH-SY5Y neuroblastoma cells: control cells) or under pathological AD condition [SH-SY5Y cells overexpressing either the human amyloid precursor protein (APP) or mutant tau (P301L)]. 30683981 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 AlteredExpression disease BEFREE PEG-modified chitosan NPs loaded with Zn(ii)-binding peptide (PEG/PZn-CS NPs) reduced Zn2+ concentrations and Aβ secretion in mouse neuroblastoma (N)2a cells stably over-expressing the APP Swedish mutation (N2aswe). 31588929 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE Using APP/PS1 Tg mice and neuroblastoma (N)2a cells as <i>in vivo</i> and <i>in vitro</i> experimental models, we observed that Ca<sup>2+</sup> stimulated the phosphorylation of tau by activating microsomal PGE synthase 1 (mPGES1) in a prostaglandin (PG) E<sub>2</sub>-dependent EP receptor-activating manner. 31143112 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE We also found that the loss of Ate1 in neuroblastoma Neuro-2a cells eliminated the apoptosis-inducing effects of peptides. 31446431 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE To test the hypothesis that Hp-s1A is a potential candidate to treat AD, we established the AD-modeled cell line by expressing human Swedish and Indiana APP gene (APP-Swe/Ind) in N2a mouse neuroblastoma cells. 30346715 2019
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE The aim of this study was to investigate the role of micro-RNA-137 (miR-137) and the CACNA1C gene in APPswe/PS1ΔE9 (APP/PS1) double-transgenic AD mice and in human neuroblastoma SH-SY5Y cells. 30102687 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 AlteredExpression disease BEFREE Furthermore, we determined that higher neuroblastoma expression of APP also associated with neurodegeneration, correlated with better neuroblastoma survival rates. 30394813 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE Furthermore, both HMI-1a3 and HMI-1b11 increased the levels of sAPPα relative to total sAPP and the ratio of Aβ42/Aβ40 in human SH-SY5Y neuroblastoma cells. 30138694 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE In this study, using genome editing technology, we mutated juxta- and intra-membrane domains of murine APP in the mouse neuroblastoma cell line, Neuro2a. 29777707 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE Additionally, S14 treatment reverted the Aβ-induced reduction in mitochondrial mass in APP/PS1 mice and in the human neuroblastoma SH-SY5Y cells co-exposed to Aβ. 29458418 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE In SH-SY5Y695 APP human neuroblastoma cell line, NCF showed better safety and efficacy against the cytotoxicity due to the significantly enhancement of cellular uptake. 30117120 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE In vitro therapeutic potential of NEF over EDR was studied against the cytotoxicity induced by copper metal ion, H<sub>2</sub>O<sub>2</sub> and Aβ42 oligomer, and cellular uptake on SH-SY5Y695 amyloid-β precursor protein (APP) human neuroblastoma cell line. 30022810 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 GeneticVariation disease BEFREE Herein, we found that sulforaphane upregulated Nrf2 expression and promoted Nrf2 nuclear translocation via decreasing DNA methylation levels of the Nrf2 promoter in mouse neuroblastoma N2a cells stably expressing human Swedish mutant amyloid precursor protein (N2a/APPswe cells), a cellular model of AD. 29382536 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE In vitro studies further show that PAI-1 increases, whereas TM5275 reduces, Aβ40 level in the culture medium of SHSY5Y-APP neuroblastoma cells. 29914038 2018
Entrez Id: 351
Gene Symbol: APP
APP
0.100 AlteredExpression disease BEFREE Furthermore, in neuroblastoma neuro-2A cells and primary superior cervical ganglion neurons, where APP is highly expressed, the lack of APP leads to a dramatic increase in plasma membrane recruitment of endogenous arrestin 3 following α<sub>2A</sub>AR activation. 28646018 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.100 AlteredExpression disease BEFREE We report here that RyR2 undergoes post-translational modifications (phosphorylation, oxidation, and nitrosylation) in SH-SY5Y neuroblastoma cells expressing the β-amyloid precursor protein (βAPP) harboring the familial double Swedish mutations (APPswe). 28476886 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.100 AlteredExpression disease BEFREE Over-expression of amyloid precursor protein in Tg2576 transgenic mice and in vitro treatment of SH-SY5Y neuroblastoma cells with the amyloidogenic Aβ42 peptide resulted in a decrease in HNK-1 immunoreactivity levels in brain and cellular extracts, whereas the levels of soluble HNK-1 glycoproteins detected in culture media were not affected by Aβ treatment. 26738850 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE We investigated this issue by analyzing the expression patterns of APP, APP-processing secretases, and APP metabolites in mitochondria separated from human neuroblastoma SH-SY5Y cells and those expressing Swedish mutant APP. 28302486 2017
Entrez Id: 351
Gene Symbol: APP
APP
0.100 Biomarker disease BEFREE Here, we investigated the effect of the nongenomic pathway induced by glucocorticoid on amyloid precursor protein processing enzymes as well as Aβ production using male ICR mice and human neuroblastoma SK-N-MC cells. 28855330 2017