Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 Biomarker disease BEFREE Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface. 30776097 2019
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE The predictive value of NTRK1-pY674/pY675 together with wild-type TP53 and low PTPN6 expression could contribute to neuroblastoma patient prognosis. 30594749 2019
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Collectively, these results indicate that EZH2 plays important roles in preventing the differentiation of NB cells and also that EZH2-related NTRK1 transcriptional regulation may be the key pathway for NB cell differentiation. 29507419 2018
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 Biomarker disease BEFREE Entrectinib's activity against both ALK and TRK proteins suggests a possible role in NB treatment, and it is currently under investigation in both pediatric and adult oncology patients. 30425456 2018
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 Biomarker disease BEFREE The over-expressions of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor TrkB have been reported to induce chemo-resistance in neuroblastoma (NB) cells. 29959561 2018
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE The aim of the present study was to investigate the effect of As<sub>2</sub>O<sub>3</sub> on Trk expression in NB cell lines and its potential therapeutic efficacy. 29898774 2018
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Consistent with this result, ZAR1-depleted NB cells showed well-differentiated phenotypes with elongated neurites and upregulated expression of TRKA and RET, which are markers for differentiated NB. 28791558 2017
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 GeneticVariation disease BEFREE Moreover, pathogenic <i>KIF1B</i>β mutations identified in neuroblastoma impair TRKA transport. 28637693 2017
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Elevated TrkA receptor expression is associated with all-trans retinoic acid-induced neuroblastoma differentiation. 26535632 2015
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 Biomarker disease BEFREE The treatment of NB cells with metformin or MIBG resulted in an increased expression of genes encoding biomarkers for favorable outcome in NB [(ephrin (EFN)B2, EFNB3, EPH receptor B6 (EPHB6), neurotrophic tyrosine kinase, receptor, type 1 (NTRK1), CD44 and Myc-interacting zinc finger protein (MIZ-1)] and tumor suppressor genes [(early growth response 1 (EGR1), EPH receptor A2 (EPHA2), growth arrest and DNA-damage-inducible, beta (GADD45B), neuregulin 1 (NRG1), TP53 apoptosis effector (PERP) and sel-1 suppressor of lin-12-like (C. elegans) (SEL1L)]. 24190252 2014
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Downregulation of TrkA protein expression by miRNA‑92a promotes the proliferation and migration of human neuroblastoma cells. 24839961 2014
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE In particular with the high-risk factors such as age of patient >1 year, MYCN amplification and low TRKA expression, the decreased expression of KLF4 was significantly associated with an unfavorable NB outcome. 23045286 2013
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma cells. 23400852 2013
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Exon-level expression analyses identify MYCN and NTRK1 as major determinants of alternative exon usage and robustly predict primary neuroblastoma outcome. 23047593 2012
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 Biomarker disease BEFREE The anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor that is involved in the pathogenesis of different types of human cancers, including neuroblastoma (NB). 21829174 2011
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 Biomarker disease BEFREE By directly connecting MYCN to the repression of TRKA and p75NTR, our findings establish a key pathway of clinical pathogenicity and aggressiveness in neuroblastoma. 21123453 2011
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 GeneticVariation disease BEFREE NTRK1 c.1810C>T polymorphism appears to be a new independent prognostic factor of poor outcome in neuroblastoma, especially in children under 18 months of age with no MYCN amplification. 20003389 2009
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Expression of Trk receptors is an important prognostic factor in neuroblastoma (NB) and other cancers. 19363525 2009
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Trk-A, p75NRT, and GRP78 overexpression are favorable prognostic factors in pediatric neuroblastoma, whereas Trk-B is associated with a poorer prognosis in these tumors. 19386345 2009
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Here, we used the SH-SY5Y human neuroblastoma cell line ectopically expressing either TrkA or TrkB as a model system to analyze the impact of Trk receptor expression on NHEJ-mediated DSB repair. 18678285 2008
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Expression of Trk receptors has been implicated in the pathogenesis and prognosis of embryonal tumors, including neuroblastoma, nephroblastoma, and medulloblastoma. 17973327 2008
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE The expression of KIT, PDGFRbeta, and FLT3 mRNA was associated with NB in patients under 1 year (P < 0.02) and TRKA expression (P < 0.001). 17941064 2008
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 Biomarker disease BEFREE Furthermore, MIZ-1 expression was positively correlated with the expression of favorable neuroblastoma genes (EFNB2, EFNB3, EPHB6, and NTRK1) in the human neuroblastoma xenograft therapeutic models. 17947461 2007
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE Because another marker of poor prognosis in neuroblastoma tumors is high expression of brain-derived neurotrophic factor (BDNF) and its tyrosine kinase receptor, TrkB, we sought to evaluate the involvement of BDNF and TrkB in the regulation of VEGF expression. 16618748 2006
Entrez Id: 4914
Gene Symbol: NTRK1
NTRK1
0.100 AlteredExpression disease BEFREE We suggest that the transcriptional program of neuroblastoma cells is modulated by Trk-receptor expression and basal activation rather than by ligand-induced activation. 15637590 2005