Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Inverse effect of the APOE epsilon4 allele in late- and early-onset Alzheimer's disease. 26714935 2017
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE The results of this study suggest that education and female gender, not APOE genotype, may be important as independent strong predictive factors for disease progression in patients with EOAD. 26444786 2016
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE None of these patients had pathogenic mutations, APOE ε4 or other high-risk alleles associated with early-onset Alzheimer's disease. 26354483 2015
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease CTD_human Elevated serum pesticide levels and risk for Alzheimer disease. 24473795 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease CTD_human Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737 2014
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Conversely, patients negative for the APOE ɛ4 allele and with early-onset AD are more likely to be predisposed to vulnerability of cerebral networks beyond the medial temporal lobes. 21185234 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease. 21576687 2011
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Most rapid cognitive decline in APOE epsilon4 negative Alzheimer's disease with early onset. 19335933 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease CTD_human Testosterone modifies the effect of APOE genotype on hippocampal volume in middle-aged men. 20819998 2010
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease CTD_human Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. 19734902 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE We analyzed the 13 SNPs in the SORL1 gene that had been studied in previous reports using case-control methods and included sex, apolipoprotein E (APOE) genotype, and age at AD onset as covariates. 19822782 2009
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE We asked the following questions: (1) Does early-onset Alzheimer disease (EOAD) occur in families with predominantly LOAD? and (2) Does the apolipoprotein E (APOE) genotype explain the wide differences in onset age in LOAD families? 16966510 2006
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE In patients with familial EOAD without the APOE epsilon4 allele, the HapB frequency further increased, to 14%, resulting in a fourfold increased risk (odds ratio = 4.1; 95% confidence interval 1.2-13.3; P=.01). 11992262 2002
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE The increased apolipoprotein E epsilon4 allele in patients without PSEN mutations confirms that it is an important risk factor in the cause of non-PSEN early-onset AD. 12433263 2002
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE apolipoprotein-E dependent role for the FAS receptor in early onset Alzheimer's disease: finding of a positive association for a polymorphism in the TNFRSF6 gene. 11129341 2001
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Presenilin-1 is a major causative gene for early onset familial Alzheimer's disease, and the apolipoprotein E epsilon4 allele is a major genetic risk factor known to influence late onset and sporadic early onset Alzheimer's disease. 10329743 1999
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE We conclude, contrary to some previous reports, that the ApoE epsilon2 allele does not increase the risk of early-onset sporadic AD. 9307262 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Apolipoprotein E genotype and concomitant clinical features in early-onset Alzheimer's disease. 8803820 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE These kindreds form the largest collection of AD cases with the same PS-1 mutation and the same educational, environmental, and ethnic background in which to study the phenotypic effect of putative risk factors, such as the epsilon4 allele of apolipoprotein E (ApoE) or head trauma. 9298817 1997
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Apolipoprotein E genotype and neuropathological phenotype in two members of a German family with chromosome 14-linked early onset Alzheimer's disease. 8525799 1996
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE The apolipoprotein E epsilon 2 allele is associated with an increased risk of early-onset Alzheimer's disease and a reduced survival. 7755355 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE The effect of the apolipoprotein E (APOE) epsilon 4 allele on age of onset was analyzed in two groups of families with early-onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early-onset non-VG families showing evidence of linkage to chromosome 14. 7574468 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 GeneticVariation disease BEFREE Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease. 7703749 1995
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease BEFREE Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia. 8075646 1994
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400 Biomarker disease CTD_human Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. 8346443 1993