Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.350 Biomarker phenotype CTD_human Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. 28448946 2017
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.350 AlteredExpression phenotype BEFREE Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention. 27388605 2016
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.350 Biomarker phenotype CTD_human Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation. 25213453 2014
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.350 Biomarker phenotype BEFREE Transgene expression of familial Alzheimer's disease-linked mutants of β-amyloid precursor protein (APP) and presenilin-1 leads to a significant inhibition of neurogenesis, which is potentially linked to age-dependent memory loss. 22042871 2011
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.350 GeneticVariation phenotype BEFREE An increased amount or mutation(s) in PS1, which alters the stoichiometric balance of the gamma-secretase complex, may be the cause of aberrant or increased processing of APP, resulting in Abeta accumulation leading to loss of memory. 19181896 2009
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.350 GeneticVariation phenotype BEFREE The objective is to describe clinical and neuropathologic features of a family with a PSEN1 mutation that has been reported previously, without autopsy confirmation, in a single Greek family whose affected members presented with memory loss in their 30s, as well as variable limb spasticity and seizures. 18580586 2008
Entrez Id: 5663
Gene Symbol: PSEN1
PSEN1
0.350 Biomarker phenotype BEFREE Recent studies have revealed that forebrain specific conditional knockouts of PS1 and PS2 genes (cPSKO) cause both neuronal degeneration and memory loss without evidence of formation of amyloid plaques. 17981591 2008