Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 Biomarker disease BEFREE Diffuse gliomas can be separated in astrocytoma and oligodendroglioma based on IDH1/2, ATRX, and TP53 mutational status. 31714292 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 Biomarker disease BEFREE Patient KK was a 68-yr-old female who was found to have a large, left-sided insular mass that was shown to be an oligodendroglioma WHO grade II, positive for codeletion 1p/19q and IDH1 mutant on biopsy. 31058967 2020
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Gliomas were assigned to one of the three molecular groups: Group O (IDH-mutant, 1p/19q co-deleted oligodendrogliomas, n = 95), Group A (IDH-mutant, ATRX inactivated astrocytomas, n = 175) and Group G (IDH wild-type, GBM-like, n = 46). 30536195 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE A total of 135 cases consisted of 38 IDH-mutant [17 astrocytoma (AC), 13 oligodendroglioma (OD) and eight glioblastoma (GBM)], 87 IDH-wildtype (six AC, three OD and 78 GBM), and 10 diffuse midline glioma, H3K27M-mutant. 30710203 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE The DSC-MRI procedure may provide insight into the IDH1/2 mutation and ATRX expression status and MGMT methylation profile of diffuse glioma; however, taking integrated oligodendroglioma into account limits the diagnostic performance of rCBV in non-invasively predicting the molecular subtype. 29468261 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE The reported two cases were initially diagnosed as oligodendroglioma with 1p/19q-codeletion and mutation of <i>isocitrate dehydrogenase 1 (IDH1)</i>-R132H. 31508376 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Patients with IDH wild type anaplastic astrocytoma and glioblastoma had a significantly shorter median PFS (19.3 months vs. NR, p = 0.001) and median OS (43.5 months vs NR, p = 0.007) than those with IDH mutated grade III anaplastic astrocytoma and oligodendroglioma. 31371189 2019
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE <i>TERT</i> promoter mutations are selectively observed among 1p/19q-codeleted oligodendrogliomas and isocitrate dehydrogenase gene- <i>(IDH-)</i> wildtype glioblastoma (GBM). 29693015 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE We excluded glioblastoma-like tumors (7a10d subgroup) and derived a gene expression signature distinguishing histologically classified oligodendrogliomas with concurrent 1p/19q co-deletion and IDH mutation (1p/19q subgroup) from those with predominant IDH mutation alone (IDHme subgroup). 29631562 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Furthermore, identification of a common IDH1 mutation in enchondroma and oligodendroglioma-matched pair specimens supports the hypothesis that IDH1/2 mosaicism initiates tumorigenesis. 29224049 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE 36 (57%) had oligodendroglioma and 27 astrocytoma.IDH-1 mutation was present in 53 (84%). 30292978 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Most tumors have a missense mutation for IDH1 combined with 1p19q codeletion in oligodendrogliomas or ATRX/TP53 mutations in astrocytomas. 29027701 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 Biomarker disease BEFREE In 2 cases, there was divergent evolution of IDH1-mutated and 1p/19q-codeleted oligodendroglioma and IDH1-mutated and 1p/19q-intact diffuse astrocytoma, occurring synchronously in one case and metachronously in a second. 29077933 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Trisomy of chromosome 7 in IDH mutated astrocytoma and PTEN mutations in IDH mutated oligodendroglioma are potential markers of poor prognosis, but require confirmation in larger series. 29663171 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Secondly, when analyzed in molecular subgroups, we were similarly unable to detect a significant PFS or OS benefit in IDH MT/codel subgroup (N = 269; HR 1.47; 95% CI 0.92-2.34; P = 0.11 and HR 1.54; 95% CI 0.78-3.05; P = 0.21, respectively), oligodendroglioma with IDH MT/codel subgroup (N = 233; HR 1.33; 95% CI 0.79-2.21; P = 0.28 and HR 1.16; 95% CI 0.53-2.54; P = 0.70, respectively) or other relevant subgroups. 30206763 2018
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 Biomarker disease BEFREE In the 2016 WHO classification, the diagnosis of oligodendroglioma has been restricted to IDH mutated, 1p19q codeleted tumors (IDHmut-codel). 29186201 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE The 25th, 50th, 75th, and 90th percentiles of MK and average MK showed significant differences between IDH1/2<sub>wild-type</sub> gliomas, IDH1/2<sub>mutated</sub> gliomas, and oligodendrogliomas with chromosome 1p/19q loss of heterozygosity and IDH1/2<sub>mutation</sub> (p<0.001). 28987669 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Distinct spectral profiles were observed for lesions with IDH-mutated genotypes, between astrocytoma and oligodendroglioma histologies, as well as for tumors that had undergone MP. 28327577 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Sixty-five patients with 2007 histological designations (astrocytomas and oligodendrogliomas), 1p/19q status (+ = intact/- = co-deleted), and IDH1 mutation status (MUT/WT) were included in this study. 28547590 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Triple-positive (IDH1 and TERT mutation with 1p19q codeletion) glioma tended to be oligodendroglioma present with much better clinical outcome compared to TERT mutation only group who is glioblastoma inclined (median overall survival 39 months VS 18 months). 28915860 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE Non-canonical IDH mutations were identified in 13/52 (25.0%) grade II gliomas (astrocytomas: 8/31, 25.8%; oligodendrogliomas: 5/21, 23.8%) and in 5/40 (12.5%) grade III gliomas (astrocytomas: 3/25, 12.0%; oligodendrogliomas: 2/15, 13.3%). 28748342 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE In the present study we searched for FGFR1-ITD by droplet digital PCR (DDPCR™) and for FGFR1 point mutations by HRM-sequencing in a series of formalin-fixed paraffin-embedded (FFPE) LGNTs including 12 DNT, 2 oligodendrogliomas lacking IDH mutation and 1p/19q co- deletion (pediatric-type oligodendrogliomas; PTOs), 3 pediatric diffuse astrocytomas (PDAs), 14 gangliogliomas (GGs) and 5 pilocytic astrocytomas (PAs). 27791984 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE The NGS approach was effective in reclassifying 36 oligoastrocytomas as 30 astrocytomas (20 IDH1/2 mutant and 10 IDH1/2 wild type) and 6 oligodendrogliomas, and 1 oligodendroglioma as an astrocytoma (IDH1/2 mutant). 28042970 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE In patients with ODG (Group 1), mutant IDH and TERTp did not have prognostic value because these mutations were universally present. 28851427 2017
Entrez Id: 3417
Gene Symbol: IDH1
IDH1
0.400 GeneticVariation disease BEFREE IDH1-R132H and 1p19q loss were found only in 12 out of the 13 oligodendrogliomas (P<0.0001). 27389560 2016