Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7161
Gene Symbol: TP73
TP73
0.060 PosttranslationalModification disease BEFREE A total of 124 of 160 glioma samples (77.5%) displayed CpG island hypermethylation of both p73, p21 genes associated with the loss of mRNA expression (P < 0.001) and the loss of protein expressions (p53 independent p21 expression). p73 gene showed increased methylation frequency in all grades, 40 of 60 (66%) glioblastomas and 16 of 30 (53.3%) anaplastic astrocytoma, 10 of 20(50%) oligodendrogliomas, 8 of 20 (40%) ependymoma, and low-grade glioma 6 of 20 (30%). 20844987 2011
Entrez Id: 7161
Gene Symbol: TP73
TP73
0.060 GeneticVariation disease BEFREE The p73 gene encodes a protein structurally and functionally homologous to TP53, and maps to chromosomal band 1p36.33, where loss of heterozygosity has been observed in up to 90% of oligodendrogliomas and in 10-25% of diffuse astrocytomas. 12200621 2002
Entrez Id: 7161
Gene Symbol: TP73
TP73
0.060 Biomarker disease BEFREE To determine whether p73 is involved in nonastrocytic brain tumour development, we analysed 65 tumour samples including 26 oligodendrogliomas, 4 ependymomas, 5 medulloblastomas, 10 meningiomas, 2 meningeal haemangiopericytomas, 2 neurofibrosarcomas, 3 primary lymphomas, 8 schwannomas and 5 metastatic tumours to the brain, for p73 alterations. 11461077 2001
Entrez Id: 7161
Gene Symbol: TP73
TP73
0.060 Biomarker disease BEFREE Thus far, mutation analysis has provided no evidence for involvement of p73 in oligodendrogliomas, lung carcinoma, oesophageal carcinoma, prostatic carcinoma and hepatocellular carcinoma. 10732753 2000
Entrez Id: 7161
Gene Symbol: TP73
TP73
0.060 Biomarker disease BEFREE The p73 gene is thus unlikely to be a tumor suppressor gene for oligodendrogliomas. 10953317 2000
Entrez Id: 7161
Gene Symbol: TP73
TP73
0.060 Biomarker disease BEFREE To determine whether p73 is a potential tumor suppressor gene involved in the development of oligodendrogliomas, we performed mutation analysis of p73 in oligodendrogliomas with chromosome 1 p-arm deletions. 9721206 1998