| Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
0.380 | Biomarker | phenotype | CTD_human | Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury. | 28762043 | 2018 | ||||
|
0.380 | Biomarker | phenotype | BEFREE | Here, we uncover a critical role for SHP in circadian regulation of cytochromes P450 (CYPs) and drug-induced hepatotoxicity. | 30555544 | 2018 | ||||
|
0.380 | GeneticVariation | phenotype | BEFREE | Association of CYP2B6 gene polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in a Chinese population. | 28389387 | 2017 | ||||
|
0.380 | GeneticVariation | phenotype | BEFREE | Association of the CYP2B6 gene with anti-tuberculosis drug-induced hepatotoxicity in a Brazilian Amazon population. | 25271170 | 2015 | ||||
|
0.380 | Biomarker | phenotype | BEFREE | Multivariate cox regression model indicated that CYP2B6*6/*6 genotype and anti-HCV IgG antibody positive as significant predictors of DILI. | 22808112 | 2012 | ||||
|
0.380 | AlteredExpression | phenotype | BEFREE | The use of hepatoma cell lines, such as HepG2 cell line, for the evaluation of drug-induced hepatotoxicity is hampered by their low cytochrome P450 expression which makes impossible the study of the toxicity produced by bioactivable compounds. | 22138474 | 2012 | ||||
|
0.380 | Biomarker | phenotype | BEFREE | CYP2B6 genotyping and/or regular monitoring of EFV and lever enzymes level during early therapy is advised for early diagnosis and management of DILI. | 21862974 | 2012 | ||||
|
0.380 | GeneticVariation | phenotype | BEFREE | Genetic polymorphisms of cytochrome P450 and glutathione S-transferase associated with antituberculosis drug-induced hepatotoxicity in Chinese tuberculosis patients. | 20819434 | 2010 | ||||
|
0.380 | GeneticVariation | phenotype | BEFREE | Risk factors for DILI include age, sex and genetic polymorphisms of drug-metabolising enzymes such as cytochrome P450. | 17967156 | 2007 |