Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker phenotype BEFREE The uncontrolled production of inflammatory factors including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and cyclooxygenase-2 (COX-2) in CILI, AILI and DILI models was also suppressed by PNP80b-2. 31712149 2019
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker phenotype BEFREE Furthermore, LPA administration decreased the production of TNF-α and IL-1β in an experimental drug-induced liver injury animal model. 29217823 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker phenotype BEFREE The canonical pathway comparison showed that VOAAF and DILI both worked on aryl hydrocarbon receptor (AHR), lipopolysaccharide (LPS)/interleukin 1 (IL-1) mediated inhibition of retinoid X receptor (RXR) function, pregnane X receptor (PXR)/RXR activation, xenobiotic metabolism, peroxisome proliferator-activated receptor (PPAR), hepatic cholestasis, farnesoid X receptor (FXR)/RXR activation, and glucocorticoid receptor. 29145837 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Therapeutic phenotype CTD_human Keratinocytes of mice at higher risk for DILI exhibited an increased IL-1β basal expression. 28138970 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 AlteredExpression phenotype BEFREE Keratinocytes of mice at higher risk for DILI exhibited an increased IL-1β basal expression. 28138970 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker phenotype CTD_human Keratinocytes of mice at higher risk for DILI exhibited an increased IL-1β basal expression. 28138970 2017
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 AlteredExpression phenotype BEFREE We investigated 30 clinical drugs with different safety profiles with regard to DILI and found that the total sum score of gene expression levels of S100A8, S100A9, RAGE, NALP3 and IL-1β mRNA in HL-60 or K562 cells incubated with HLM, could identify drugs at high risk for hepatotoxicity. 24747151 2014
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Therapeutic phenotype CTD_human Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. 19164858 2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker phenotype CTD_human Acetaminophen-induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome. 19164858 2009
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.360 Biomarker phenotype BEFREE It seems that treatment of acute and chronic infections and/or inflammations with, for example, antibacterials not metabolized in the liver, and use of medications that decrease proinflammatory cytokine levels (eg, pentoxifylline, a TNF-alpha synthesis inhibitor, directed against TNF-alpha-induced priming of human neutrophils, immunotherapy with IL-4, IL-1 receptor antagonists or factors inducing IL-1ra, dietary supplementation with long-chain n-3 fatty acids, and other antioxidant agents) may perhaps, in some cases, be helpful in the prevention and management of drug-induced hepatotoxicity. 15891270 2005