Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 GeneticVariation phenotype BEFREE Interleukin-4 and interleukin-10 polymorphisms and antituberculosis drug-induced hepatotoxicity in Chinese population. 25308608 2015
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 Therapeutic phenotype CTD_human Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice. 22107450 2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 Biomarker phenotype CTD_human Endogenous interleukin-4 regulates glutathione synthesis following acetaminophen-induced liver injury in mice. 22107450 2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 Therapeutic phenotype CTD_human Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. 21735453 2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 Biomarker phenotype CTD_human Involvement of Th2 cytokines in the mouse model of flutamide-induced acute liver injury. 21735453 2012
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 Biomarker phenotype CTD_human IL-4 mediates dicloxacillin-induced liver injury in mice. 21094227 2011
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 Therapeutic phenotype CTD_human IL-4 mediates dicloxacillin-induced liver injury in mice. 21094227 2011
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 GeneticVariation phenotype BEFREE IL-10, IL-4 and TNF-alpha genetic polymorphisms were not related to the risk of developing DILI. 18485518 2008
Entrez Id: 3565
Gene Symbol: IL4
IL4
0.330 Biomarker phenotype BEFREE It seems that treatment of acute and chronic infections and/or inflammations with, for example, antibacterials not metabolized in the liver, and use of medications that decrease proinflammatory cytokine levels (eg, pentoxifylline, a TNF-alpha synthesis inhibitor, directed against TNF-alpha-induced priming of human neutrophils, immunotherapy with IL-4, IL-1 receptor antagonists or factors inducing IL-1ra, dietary supplementation with long-chain n-3 fatty acids, and other antioxidant agents) may perhaps, in some cases, be helpful in the prevention and management of drug-induced hepatotoxicity. 15891270 2005