Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE <b>Conclusion</b>: Taken together, we demonstrated that EGF secreted by M2-like TAMs might suppress LIMT expression via activating EGFR-ERK signaling pathway to promote the progression of OC. 31062668 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Anti-EpCAM-conjugated adeno-associated virus serotype 2 for systemic delivery of EGFR shRNA: Its retargeting and antitumor effects on OVCAR3 ovarian cancer in vivo. 31026519 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE The inhibitory profile of 7h against a panel of patient-derived tumor cell lines was established, demonstrating selective growth inhibition of EGFR related cells at 10 μM among a panel of 30 cell lines derived from colon, melanoma, breast, bladder, kidney, prostate, pancreas and ovary tumors. 30626888 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Pyruvate dehydrogenase kinase 1 contributes to cisplatin resistance of ovarian cancer through EGFR activation. 30229902 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Thus, Cx32 expression may induce cisplatin resistance by modulating drug efflux transporter expression and activating the EGFR‑protein kinase B signalling pathway in ovarian cancer cells. 30664215 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE <i>KRAS</i> mutations and the protein expression of EGFR and PKC-alpha should be evaluated as predictive biomarkers in patients with LGSC treated with MEKi. 30636931 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Clinical significance of growth factor receptor EGFR and angiogenesis regulator VEGF‑R2 in patients with ovarian cancer at FIGO stages I-II. 30066848 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE These results may be beneficial to better understand the molecular underpinning of OC and may be useful to develop tools for more accurate OC prognosis and for promoting the development of EGFR-targeted inhibitors for OC treatment. 30588099 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Enhanced Chemotherapeutic Efficacy of Paclitaxel Nanoparticles Co-delivered with MicroRNA-7 by Inhibiting Paclitaxel-Induced EGFR/ERK pathway Activation for Ovarian Cancer Therapy. 29411964 2018
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE It is reported the expression of HCRP1 is inversely related to epidermal growth factor receptor (EGFR) in breast cancer and lead to resistance to cetuximab in ovarian cancer. 28122307 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE NRF2 Regulates HER1 Signaling Pathway to Modulate the Sensitivity of Ovarian Cancer Cells to Lapatinib and Erlotinib. 29410730 2017
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Amphiregulin (AREG) binds exclusively to the epidermal growth factor receptor (EGFR) and has been considered to be a dominant autocrine/paracrine EGFR ligand in ovarian cancer. 26768617 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Amphiregulin (AREG), the most abundant EGFR ligand in ovarian cancer, binds exclusively to EGFR and stimulates ovarian cancer cell invasion by down-regulating E-cadherin expression. 27835572 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE In this study we explore protein expression as well as gene mutations and amplifications of EGFR in BOTs in comparison to a subset of other epithelial ovarian tumours. 26870997 2016
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE In the current study, we investigated the mechanisms of erlotinib used alone or in combination with olaparib (AZD2281), a potent inhibitor of PARP, in an EGFR-overexpressing ovarian tumor xenograft model. 26124641 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Some miR-7 targets, including B-cell lymphoma 2 (BCL2) and epidermal growth factor receptor (EGFR), are involved in ovarian cancer (OC) pathogenesis. 25862909 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Our results showed that the mRNA level of miR-133b was remarkably decreased in OC cell lines compared with normal colon epithelium cells, whereas the protein expression of EGFR was significantly increased. 26617770 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Both epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor 1 (FGFR1) are overexpressed in the majority of human tumors, including ovarian cancer. 25919378 2015
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Epidermal growth factor receptor (EGFR) overexpression and activation result in increased proliferation and migration of solid tumors including ovarian cancer. 24816687 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Here, we investigated the mechanisms of crosstalk between PAFR and EGFR signaling in ovarian cancer cells to further determine whether the interaction between PAFR and EGFR synergistic contribute to the progression of ovarian cancer. 25261977 2014
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE EGFR mediates LPA-induced proteolytic enzyme expression and ovarian cancer invasion: inhibition by resveratrol. 23127547 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE Targeting EGFR and PI3K pathways in ovarian cancer. 24022196 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 AlteredExpression disease BEFREE Additionally, EGFR expression was higher in normal tissues of BRCA1-mutated patients, and was further increased in cancer tissues; EGFR levels were also significantly elevated in ovarian cancer with promoter hypermethylation-mediated inactivation of BRCA1. 24321281 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease BEFREE To elucidate the role of epidermal growth factor receptor (EGFR) signalling in ovarian cancer, we analyzed 23 primary tumors and corresponding metastases for the expression of 25 proteins involved in EGFR signalling with special emphasis on epithelial-mesenchymal transition (EMT). 23913224 2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.400 Biomarker disease CTD_human Analysis of human ovarian cancer patients' tumor tissues shows aberrantly-active EGFR and Stat3 that in certain cases correlate with Vimentin over-expression. 21909139 2012