Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 AlteredExpression disease BEFREE Low MLH1 expression was associated with improved prognosis and is a possible predictor of the chemosensitivity of ovarian cancer. 31570444 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease BEFREE Correction: The hMLH1 -93G>A Polymorphism and Risk of Ovarian Cancer in the Chinese Population. 31150525 2019
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease BEFREE Among MLH1 mutation carriers, mutations in MLH1 were associated with colorectal cancer in 249 (61%) of 409 men and women; endometrial cancer in 53 of 196 (27%) women; and ovarian cancer in 15 (8%) of 196 women. 28772289 2017
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease BEFREE These findings indicate that the -93G>A polymorphism in hMLH1 may affect ovarian cancer susceptibility in the Chinese population. 26275295 2015
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease BEFREE Based on recent estimates that 11.7-16.6 % of women with ovarian cancer are BRCA carriers and 2 % are HNPCC carriers, results suggest under-identification of carriers and under-utilization of genetic services by providers and patients. 23677535 2013
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease BEFREE Our findings suggest that fewer than 1% of women with ovarian cancer harbour a germline mutation in the HNPCC genes, with overrepresentation of MSH6 mutations. 23047549 2012
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 PosttranslationalModification disease BEFREE Furthermore, 5/13 genes (ARMCX2, COL1A1, MDK, MEST and MLH1) acquired methylation in drug-resistant ovarian cancer-sustaining (side population) cells. 22249249 2012
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 PosttranslationalModification disease BEFREE Studies examining MSI, loss of MMR gene expression by IHC staining and MLH1 promoter hypermethylation in ovarian cancer were identified by a systematic literature search of the PubMed electronic database through August 31, 2009. 21140452 2011
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 AlteredExpression disease LHGDN Ovarian cancer tissues were obtained from 61 patients: 45 platinum-sensitive and 16 platinum-resistant. hMLH1 and hMSH2 proteins expression was evaluated by immunohistochemistry, with the use of mouse monoclonal antibodies clone 14 for hMLH1 and clone FE11 for hMSH2. 19175039 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 AlteredExpression disease BEFREE Our results indicate that promoter hypermethylation is an important mechanism for loss of hMLH1 and hMSH2 expression in human ovarian cancer and may be a potential prognostic factor in ovarian cancer. 19032668 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease LHGDN The G>A nt-93 variant of the MLH1 gene is associated with an increased risk of invasive ovarian cancer. 18405947 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 Biomarker disease CTD_human We examined the methylation status of hMLH1 and hMSH2 promoter region by methylation-specific polymerase chain reaction (MSP) in 56 primary ovarian cancer tissues and 20 normal ovarian tissues, the relationship between the methylation status of these two genes and clinicopathological characteristics were analysed. 19032668 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease BEFREE Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1. 18405947 2008
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 AlteredExpression disease BEFREE The purpose of our study was to determine the likelihood of MMR defects (MSH2, MSH6, MLH1) in women with synchronous endometrial and ovarian cancer. 16361634 2005
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 PosttranslationalModification disease LHGDN These data support the clinical relevance of acquired hMLH1 methylation and concomitant loss of DNA MMR after chemotherapy of ovarian cancer patients. 15240532 2004
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 PosttranslationalModification disease BEFREE Serial 5'-deletion studies of the hMLH1 promoter region in ovarian cancer cells localized transcriptional enhancers to a region (-250 to -151 bp) that excludes the previously identified CCAAT element (-282) active in HeLa cells. 12805408 2003
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 AlteredExpression disease BEFREE We studied the correlation between loss of hMLH1 expression in tumour cells and clinical outcome in 38 patients with ovarian cancer, who underwent cisplatin-based chemotherapy. 12736115 2003
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease LHGDN 1) Coding DNA instability is likely to be a very rare event in OC and, therefore, may not significantly contribute to the development of OC, and 2) the high frequency of LOH at hMLH1 observed in our ovarian tumors suggests that further investigation is needed to determine if such a trend exists in other mismatch DNA repair and/or critical genes. 12014680 2002
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 Biomarker disease BEFREE 1) Coding DNA instability is likely to be a very rare event in OC and, therefore, may not significantly contribute to the development of OC, and 2) the high frequency of LOH at hMLH1 observed in our ovarian tumors suggests that further investigation is needed to determine if such a trend exists in other mismatch DNA repair and/or critical genes. 12014680 2002
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 PosttranslationalModification disease BEFREE Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors. 11753956 2001
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 AlteredExpression disease BEFREE This analysis suggests that methylation of the hMLH1 promoter may be a common mechanism for loss of hMLH1 expression, and possibly for cisplatin-resistance, in ovarian cancer. 10327053 1999
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease BEFREE The fact that we found no germline pathologic mutations in hMSH2 and hMLH1 (predominant sites of mutation in HNPCC) in MIN+ OC cases, suggests that the genetic basis of MIN in OC can be different from that in HNPCC; our finding that distinct microsatellite banding patterns largely distinguish sporadic from familial OC, may reflect the involvement of different DNA repair genes in MIN in individual OC cases. 8824498 1996
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GeneticVariation disease BEFREE Amongst the important known susceptibility genes are those dominant genes conferring a high risk of breast and ovarian cancer (BRCA1), colon cancer (hMSH2 and hMLH1), and melanoma (MLM). 7987639 1994
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 Biomarker disease HPO
Entrez Id: 4292
Gene Symbol: MLH1
MLH1
0.700 GenomicAlterations disease CGI