Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease BEFREE In contrast, beta-catenin is not a good indicator of metastasis in human ovarian carcinoma. 11182035 2001
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE To summarize, the results of this study suggest that beta-catenin mutations and MI could represent two independent pathways in endometrioid ovarian carcinomas because they occur simultaneously very infrequently (in 5% of these cases). beta-catenin mutations are always associated with a nuclear beta-catenin expression pattern, whereas cases with a replication error -plus phenotype showed no abnormal beta-catenin subcellular localization. 11385321 2001
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 AlteredExpression disease BEFREE A recent report describing the presence of beta-catenin mutations in endometrioid ovarian cancer suggested that the TCF/beta-catenin pathway may be generally activated in ovarian cancer. 10739697 2000
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 AlteredExpression disease BEFREE Both nuclear and cytoplasmic beta-catenin expressions were demonstrated in 4 of the 27 ovarian carcinomas for which tissue samples were available for examination. 10391090 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE beta-catenin mutation and expression analysis in ovarian cancer: exon 3 mutations and nuclear translocation in 16% of endometrioid tumours. 10417756 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 AlteredExpression disease BEFREE The immunohistochemical expression pattern of beta-catenin has been correlated with beta-catenin gene mutations, clinicopathological features, and disease outcome in 69 stage I and II ovarian carcinomas. beta-Catenin expression was localized in the nuclei, in addition to the cytoplasm and membrane, in 11 tumors (16%): nine endometrioid carcinomas with widespread nuclear expression and two serous carcinomas with focal nuclear expression. 10433945 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease UNIPROT Both nuclear and cytoplasmic beta-catenin expressions were demonstrated in 4 of the 27 ovarian carcinomas for which tissue samples were available for examination. 10391090 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 GeneticVariation disease BEFREE Mutations in the beta-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. 9537226 1998
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 CausalMutation disease CGI
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.900 Biomarker disease MGD
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 Biomarker disease BEFREE Immunohistochemistry for the detection of BRCA1 and BRCA2 proteins in patients with ovarian cancer: a systematic review. 31719105 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 Biomarker disease BEFREE Comprehensive Profiling of BRCA1 and BRCA2 Variants in Breast and Ovarian Cancer in Chinese Patients. 31825140 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE In the present study, 21 BRCA1 and BRCA2 pathogenic variants were detected in 30 patients and BRCA1/2 mutations were significantly associated with a family history of breast/ovarian cancer. 31706072 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Olaparib as maintenance therapy in patients with BRCA 1-2 mutated recurrent platinum sensitive ovarian cancer: Real world data and post progression outcome. 31699415 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE A simultaneous detection of germline and somatic mutations in ovarian cancer (OC) using tumor materials is considered to be cost-effective for <i>BRCA1/2</i> testing. 31788999 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 Biomarker disease BEFREE Germline mutations (eg, BRCA1/2) have prognostic and treatment implications for ovarian cancer (OVCA) patients. 31600840 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Comprehensive Profiling of BRCA1 and BRCA2 Variants in Breast and Ovarian Cancer in Chinese Patients. 31825140 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE In the present study, 21 BRCA1 and BRCA2 pathogenic variants were detected in 30 patients and BRCA1/2 mutations were significantly associated with a family history of breast/ovarian cancer. 31706072 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Analyses performed under logistic model, linear mixed model, and model incorporating correlations identified nine significant associations with three gynecologic diseases including four novel findings (rs79219469:C > T, LINC02183, P = 3.3 × 10<sup>-8</sup> and rs567534295:C > T, BRCA1, P = 3.1 × 10<sup>-8</sup> with OC, rs150806792:C > T, INS-IGF2, P = 4.9 × 10<sup>-8</sup> and rs140991990:A > G, SOX9, P = 3.3 × 10<sup>-8</sup> with UCC). 31488892 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 Biomarker disease BEFREE Immunohistochemistry for the detection of BRCA1 and BRCA2 proteins in patients with ovarian cancer: a systematic review. 31719105 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE This consensus guide represents a collection of technical recommendations to address the detection of BRCA1/2 mutations in the molecular diagnostic testing strategy for OC. 31797087 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 Biomarker disease BEFREE BRCA1-driven OCs demonstrate the plasticity of BRCA1 status during the treatment course. 31693165 2020
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 Biomarker disease BEFREE Universal tumor DNA BRCA1/2 testing of ovarian cancer: prescreening PARPi treatment and genetic predisposition. 31076742 2020
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Overall, 178/2192 (8.1%) evaluable OC women showed pathogenic germline mutations in BRCA genes (84 BRCA1;94 BRCA2). 31253107 2019
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 Biomarker disease BEFREE However, analyses that considered all 41 genes with clinical variables together identified genes TLR4, BSCL2, CDH1, ERBB2, BRCA2 and SCGB2A1 as independently related to survival in OC. 31655274 2019