Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 AlteredExpression disease BEFREE Ovarian cancer tissues showed lower miR-203a-3p levels and higher ATM levels than adjacent normal tissues, both of which were associated with the FIGO stage, grade and prognosis of ovarian cancer. 31277702 2019
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 Biomarker disease BEFREE <i>Chlamydia trachomatis</i> infections are epidemiologically associated with cervical and ovarian cancers.Previously, we showed that <i>C. trachomatis</i> induces DNA double-strand breaks (DSBs) but suppresses Ataxia-telangiectasia mutated (ATM) activation and cell cycle checkpoints. 30401777 2018
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 Biomarker disease BEFREE The recent approval of three different PARP inhibitors for the treatment of ovarian cancer provides the impetus for further developing targeted inhibitors of many of the kinases involved in the DDR, including inhibitors of ATR, ATM, CHEK1, CHEK2, DNAPK and WEE1. 28984489 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 Biomarker disease BEFREE Relative risks of ovarian cancer greater than two-fold were also observed for ATM, but could reliably be ruled out for RAD50 and CHEK2. 28888541 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 GeneticVariation disease BEFREE Challenges in Interpreting Germline Mutations in BARD1 and ATM in Breast and Ovarian Cancer Patients. 28139868 2017
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 GeneticVariation disease BEFREE Thirty-one percent of ovarian carcinomas had a deleterious germline (24%) and/or somatic (9%) mutation in one or more of the 13 homologous recombination genes: BRCA1, BRCA2, ATM, BARD1, BRIP1, CHEK1, CHEK2, FAM175A, MRE11A, NBN, PALB2, RAD51C, and RAD51D. 24240112 2014
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 GeneticVariation disease BEFREE Contributions of ATM mutations to familial breast and ovarian cancer. 12810666 2003
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 GeneticVariation disease BEFREE One of the many substrates of ATM is BRCA1 (breast cancer 1, early onset gene), which has been associated with susceptibility to breast and ovarian cancer, and has been implicated in DNA repair processes. 14630541 2003
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 Biomarker disease BEFREE To investigate the role of ATM in ovarian cancer, we used a PCR-based single-strand conformation polymorphism assay for mutation detection of the entire coding sequence of the ATM gene (65 exons) in 22 ovarian tumors. 9949303 1999
Entrez Id: 472
Gene Symbol: ATM
ATM
0.190 GeneticVariation disease CLINVAR