Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Our findings reveal that NORAD/miR-608/STAT3 axis is pivotal in mediating the antineoplastic impacts of PG on ovarian cancer cells, which may offer a novel explanation in the therapy of ovarian cancer. 31299866 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE MicroRNA-503-5p Inhibits the CD97-Mediated JAK2/STAT3 Pathway in Metastatic or Paclitaxel-Resistant Ovarian Cancer Cells. 30622051 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Less is known about the role of LIF, which can similarly activate STAT3, in ovarian cancer. 30305729 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Knockdown of HE4 suppresses aggressive cell growth and malignant progression of ovarian cancer by inhibiting the JAK/STAT3 pathway. 31477564 2019
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE In conclusion, the present study proved for the first time that miR-519a functions as a tumor suppressor by targeting STAT3 in ovarian cancer, suggesting that miR-519a may be a potential biomarker for the diagnosis and treatment of ovarian cancer. 29434770 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Therefore, these compounds may serve as candidate compounds for further modification and development as anticancer therapeutics targeting the DBD of human STAT3 for treatment of cisplatin-resistant ovarian cancer. 30145375 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE In addition, phosphorylated-Stat3 (Tyr705) amounts OC cell invasion and migration, and expression of matrix metalloproteinases (MMP-9 and MMP-2) decreased. 30182276 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE STAT3 regulated <i>miR-216a</i> promotes ovarian cancer proliferation and cisplatin resistance. 30061175 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Effect of combined inhibition of p110 alpha PI3K isoform and STAT3 pathway in ovarian cancer platinum-based resistance. 29930760 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Molecular design of Stat3-derived peptide selectivity between BET proteins Brd2 and Brd4 in ovarian cancer. 28983974 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE The activation of JAK2/STAT3 pathway had significant impact on survival of ovarian cancers, especially for the cases with clear-cell histology. 29545902 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE CONCLUSIONS Our study demonstrated that FEZF1-AS1 exerted an oncogenic role in ovarian cancer via modulating JAK-STAT3 pathway. 30416194 2018
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Intriguingly, we demonstrated that M-MDSC could be readily induced by ascitic fluids (AF) from OC patients, which was predominantly dependent on IL-6, IL-10 and STAT3 activation as neutralization of IL-6 and/or IL-10 or inhibition of STAT3 abrogated MDSC's expansion while recombinant IL-6 and IL-10 recapitulated the expansive effect of AF; furthermore, predominantly elevated levels of IL-6 and IL-10 has been noted in the AF which was positively correlated with the abundance of M-MDSC as well as poor prognosis of OC patients. 29100353 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE The STAT3-miRNA-92-Wnt Signaling Pathway Regulates Spheroid Formation and Malignant Progression in Ovarian Cancer. 28209618 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Elevated STAT3 expression in ovarian cancer ascites promotes invasion and metastasis: a potential therapeutic target. 27292260 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Quercetin induces protective autophagy and apoptosis through ER stress via the p-STAT3/Bcl-2 axis in ovarian cancer. 28188387 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 PosttranslationalModification disease BEFREE These results suggest that the phosphorylation of STAT3 regulates MMP-9 production in ovarian cancer, which might be responsible for its invasiveness and metastasis. 28859117 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Follow-up was performed to explore relationship of HER2, SOCS3, and STAT3 expressions with survival time of OC patients. 28448787 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Phenethyl isothiocyanate suppresses the metastasis of ovarian cancer associated with the inhibition of CRM1-mediated nuclear export and mTOR-STAT3 pathway. 27981892 2017
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Furthermore, anti-miR551b reduced STAT3 expression in ovarian cancer cells in vitro and in vivo and reduced ovarian cancer growth in vivo. 27160903 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE We further demonstrated that a STAT3/JAK2 inhibitor could potently sensitize platinum-resistant cells to carboplatin and suppress their growth in vivo Our findings offer a mechanistic rationale to target the PBX1/STAT3 axis to antagonize a key mechanism of chemoresistance in ovarian cancers and possibly other human cancers. 27590741 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Cisplatin-induced CCL5 secretion from CAFs promotes cisplatin-resistance in ovarian cancer via regulation of the STAT3 and PI3K/Akt signaling pathways. 26983899 2016
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE Results of the present study suggested that combined therapy with eukaryotic co-expression of the plasmid‑carrying STAT3-specific siRNA and LKB1 is a novel and efficient treatment strategy for human ovarian cancer. 25420630 2015
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 Biomarker disease BEFREE Our results offer preclinical proof-of-concept for HO-3867 as a selective STAT3 inhibitor to treat ovarian cancer and other solid tumors where STAT3 is widely upregulated. 24590057 2014
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
0.400 AlteredExpression disease BEFREE JAK/STAT3 is one of the major signaling pathways that is aberrantly activated in ovarian cancer and associated with tumor progression and poor prognosis in patients with ovarian cancer. 25319391 2014