Gene | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
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0.380 | Biomarker | disease | BEFREE | This study demonstrated that pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer, which may explain why up-regulated DR4 and DR5 in ovarian cancer are associated with poor prognosis and low survival ratio of the patients. | 27780136 | 2016 | ||||
|
0.380 | GeneticVariation | disease | BEFREE | Considering a multiple-testing-corrected significance threshold of P < 2.5 × 10(-5), only one other variant, the TNFSF10 SNP rs6785617, was associated significantly with a risk of ovarian cancer (low malignant potential tumors OR, 0.85; 95% CI, 0.79-0.91; P = 0.00002). | 24272484 | 2014 | ||||
|
0.380 | Biomarker | disease | BEFREE | GT-oligo was found to induce transcript expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors DR-4 and DR-5, which are generally silenced in ovarian cancer cells, rendering them insensitive to TRAIL. | 23634944 | 2013 | ||||
|
0.380 | Therapeutic | disease | CTD_human | TLR4 activates NF-κB in human ovarian granulosa tumor cells. | 21616060 | 2011 | ||||
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0.380 | Biomarker | disease | BEFREE | Our findings indicate that c-FLIP(L) regulates sensitivity of OC to TRAIL-mediated apoptosis and offers possible therapeutical implications for OC in the future. | 20227749 | 2010 | ||||
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0.380 | Biomarker | disease | BEFREE | TRAIL resistance in ovarian carcinomas can be caused by a blockade upstream of the caspase 3 signaling cascade. | 19540229 | 2009 | ||||
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0.380 | Biomarker | disease | BEFREE | Resistance to TRAIL-induced apoptosis in ovarian cancer cell lines is overcome by co-treatment with cytotoxic drugs. | 15262127 | 2004 | ||||
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0.380 | Biomarker | disease | BEFREE | Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft. | 12365003 | 2002 | ||||
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0.380 | Biomarker | disease | BEFREE | The combination of TRAIL and chemotherapy could be useful as a therapy for chemoresistant ovarian cancers. | 11371126 | 2001 |