Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 Biomarker disease BEFREE This study demonstrated that pro-survival effects by NF-κB, Akt and ERK(1/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4/5 pathway in ovarian cancer, which may explain why up-regulated DR4 and DR5 in ovarian cancer are associated with poor prognosis and low survival ratio of the patients. 27780136 2016
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 GeneticVariation disease BEFREE Considering a multiple-testing-corrected significance threshold of P < 2.5 × 10(-5), only one other variant, the TNFSF10 SNP rs6785617, was associated significantly with a risk of ovarian cancer (low malignant potential tumors OR, 0.85; 95% CI, 0.79-0.91; P = 0.00002). 24272484 2014
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 Biomarker disease BEFREE GT-oligo was found to induce transcript expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors DR-4 and DR-5, which are generally silenced in ovarian cancer cells, rendering them insensitive to TRAIL. 23634944 2013
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 Therapeutic disease CTD_human TLR4 activates NF-κB in human ovarian granulosa tumor cells. 21616060 2011
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 Biomarker disease BEFREE Our findings indicate that c-FLIP(L) regulates sensitivity of OC to TRAIL-mediated apoptosis and offers possible therapeutical implications for OC in the future. 20227749 2010
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 Biomarker disease BEFREE TRAIL resistance in ovarian carcinomas can be caused by a blockade upstream of the caspase 3 signaling cascade. 19540229 2009
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 Biomarker disease BEFREE Resistance to TRAIL-induced apoptosis in ovarian cancer cell lines is overcome by co-treatment with cytotoxic drugs. 15262127 2004
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 Biomarker disease BEFREE Combined TRAIL and Bax gene therapy prolonged survival in mice with ovarian cancer xenograft. 12365003 2002
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
0.380 Biomarker disease BEFREE The combination of TRAIL and chemotherapy could be useful as a therapy for chemoresistant ovarian cancers. 11371126 2001