Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.810 GeneticVariation disease BEFREE We studied nine single nucleotide polymorphisms (SNPs) located in CTNNB1 (β-catenin) [rs4533622, rs2953], APC (rs11954856, rs351771, rs459552), and AXIN2 (rs4074947, rs7224837, rs3923087, rs2240308) in women with ovarian cancer without BRCA1/BRCA2 mutations (n = 228) and controls (n = 282). 24078348 2014
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.810 Biomarker disease CTD_human It was demonstrated that ovarian cancer constantly exhibit constitutive activation of canonical Wnt signaling, usually as a result of oncogenic mutations that stabilize and dysregulate the β-catenin protein. 22000491 2012
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.810 GeneticVariation disease UNIPROT Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: frequent mutations in endometrioid carcinomas. 10391090 1999
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.810 CausalMutation disease CGI
Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
0.810 Biomarker disease MGD
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE BRCA1 germline mutation confers hereditary predisposition for breast and ovarian cancer. 29034880 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 Biomarker disease BEFREE Universal BRCA1/BRCA2 Testing for Ovarian Cancer Patients is Welcomed, but with Care: How Women and Staff Contextualize Experiences of Expanded Access. 28540621 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 Biomarker disease BEFREE Genetic Versus Epigenetic BRCA1 Silencing Pathways: Clinical Effects in Primary Ovarian Cancer Patients: A Study of the Tumor Bank Ovarian Cancer Consortium. 28691938 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in high-grade serous ovarian cancers in the maintenance setting. 28525389 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Approximately 20% of high-grade serous ovarian cancers are homologous-recombination (HR)-deficient due to genetic and epigenetic mutations of HR pathway genes including the tumor suppressor genes BRCA1 and 2. 28866885 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Association of BRCA1/2 mutations with ovarian cancer prognosis: An updated meta-analysis. 29480828 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 Biomarker disease BEFREE Long non-coding RNA RP11-552M11.4 promotes cells proliferation, migration and invasion by targeting BRCA2 in ovarian cancer. 29478268 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE The present case is the first report in Japan in which a breast cancer was discovered as a result of prospective magnetic resonance imaging (MRI) screening study for BRCA1/2 mutation carriers who were free of breast or ovarian cancer. 28090007 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 GeneticVariation disease BEFREE The First Nationwide Multicenter Prevalence Study of Germline BRCA1 and BRCA2 Mutations in Chinese Ovarian Cancer Patients. 28692638 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Diagnostic markers for the detection of ovarian cancer in BRCA1 mutation carriers. 29244844 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Germline mutations in BRCA1/BRCA2 significantly increase the risk of breast and ovarian cancer in women. 28780755 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE We report a novel BRCA1 LGR, involving the complete duplication of exon 3, in an Italian patient with a strong family history of breast and ovarian cancer. 28488140 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Biological and clinical evidence for somatic mutations in BRCA1 and BRCA2 as predictive markers for olaparib response in high-grade serous ovarian cancers in the maintenance setting. 28525389 2018
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
0.800 GeneticVariation disease BEFREE The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer. 27622768 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Combined annotation-dependent depletion score for BRCA1/2 variants in patients with breast and/or ovarian cancer. 29215753 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Predictability of BRCA1/2 mutation status in patients with ovarian cancer: How to select women for genetic testing in middle-income countries. 28619461 2018
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
0.800 Biomarker disease BEFREE Changes in gene expression variability reveal a stable synthetic lethal interaction network in BRCA2-ovarian cancers. 28754563 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease UNIPROT We identified the BRCA1/2 genetic mutation test results of 1223 breast cancer patients and 174 patients with ovarian cancer. 28364669 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 Biomarker disease BEFREE Chemosensitivity of BRCA1-Mutated Ovarian Cancer Cells and Established Cytotoxic Agents. 28604461 2018
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
0.800 GeneticVariation disease BEFREE Evaluation of copy number variation (CNV) in BRCA1/2 genes, due to large genomic rearrangements (LGRs), is a mandatory analysis in hereditary breast and ovarian cancers families, if no pathogenic variants are found by sequencing. 28465148 2018