Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Overall, our results demonstrate novel evidence that the paracrine NGF/TrkA axis favors EMT and confers EGFR-targeted therapeutic resistance in HNSCC. 31838083 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Targeting EGFR in combination with conventional chemotherapy might be a promising strategy for the treatment of HNSCC through elimination of cancer stem cells. 31823521 2020
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Importantly, recent evidence has emerged supporting also an immune-modulatory effect of EGFR inhibition, and interest has now focused on utilizing these effects in the current treatment approaches for SCCHN. 31676542 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Interestingly, we show that EGFR blockade inhibits <i>EREG</i> expression, and that <i>EREG</i> knock-down decreases basal cell clonogenic survival, suggesting that <i>EREG</i> expression could be a predictive functional marker of sensitivity to EGFR blockade in basal-like HNSCC. 31181806 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE The most common abnormalities downstream from EGFR in HNSCC are in the PI3K pathway, activated via loss of expression of the regulator PTEN, or via PI3K mutation. 30926065 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells. 31462653 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Cetuximab is a chimeric monoclonal antibody against epidermal growth factor receptor (EGFR) and it is approved for treatment of human colorectal cancer and squamous cell carcinoma of head and neck. 31112673 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Mechanism of action of Cetuximab could be immune-mediated rather than EGFR inhibition and EGFR may not necessarily be a therapeutic target in SCCHN. 30701564 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Mechanistically, high levels of Arf1 activity are maintained by binding to phosphorylated EGFR which is localized on HNSCC cell plasma membrane. 30777099 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Here, we examined the responses of a large panel of patient-derived HNSCC cell lines to various combinations of PI3K and EGFR inhibitors, including EGFR agents with varying specificity and mechanistic characteristics. 30858165 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Epidermal growth factor receptor (EGFR) targeted therapies have shown limited efficacy in head and neck squamous cell carcinoma (HNSCC) patients despite its overexpression. 31827134 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Long non-coding RNA LINC00052 regulates miR-608/EGFR axis to promote progression of head and neck squamous cell carcinoma. 31639333 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Overall, the present data suggest that cetuximab treatment in combination with ALT-803 in patients with EGFR-positive SCCHN may result in significant NK cell activation and have important anti-tumor activity. 31338557 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Using metabolic imaging, we were able to identify hyperpolarized <sup>13</sup>C-pyruvate as a potential marker for response and resistance to the EGFR inhibitor in HNSCC. 31831557 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Using a novel cohort of patients with head and neck squamous cell carcinoma (HNSCC), we investigated mechanisms of immune escape from epidermal growth factor receptor-specific monoclonal antibody (mAb) therapy. 30828910 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Similarly, EGFR was analyzed in HNSCCs (N = 21). 31345374 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE The inhibitory epidermal growth factor receptor (EGFR) antibody, cetuximab, is an approved therapy for head and neck squamous cell carcinoma (HNSCC). 31554698 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Vandetanib sensitizes head and neck squamous cell carcinoma to photodynamic therapy through modulation of EGFR-dependent DNA repair and the tumour microenvironment. 31299389 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 AlteredExpression disease BEFREE Epidermal growth factor receptor (EGFR) overexpression is common in head and neck squamous cell carcinoma. 30700700 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Fluorescein- and EGFR-Antibody Conjugated Silica Nanoparticles for Enhancement of Real-time Tumor Border Definition Using Confocal Laser Endomicroscopy in Squamous Cell Carcinoma of the Head and Neck. 31561451 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Trials on assessing the benefits of EGFR inhibitors in head and neck squamous cell carcinoma (HNSCC) patients have gradually been published. 31239839 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE We systematically searched literature for randomized controlled trials comparing chemotherapy or radiotherapy with versus without EGFR inhibitors in locoregionally advanced, recurrent, or metastatic HNSCCs. 30819445 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Cetuximab, an EGFR-blocking antibody, is currently approved for treatment of metastatic head and neck squamous cell carcinoma (HNSCC), but its response rate is limited. 31578313 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE We therefore sought to identify cellular mechanisms that cause resistance to EGFR inhibition and radiotherapy in HNSCC. 31387891 2019
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
0.500 Biomarker disease BEFREE Here, we identified two enhancers (CE1 and CE2) present within the first intron of the <i>EGFR</i> gene in models of glioblastoma (GBM) and head and neck squamous cell carcinoma (HNSCC). 31444232 2019