Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.360 AlteredExpression disease BEFREE Baseline serum levels of IL-1α were measured using ELISA from HNSCC patients treated with cetuximab-based therapy and analyzed for association with progression free survival (PFS). 30890189 2019
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.360 AlteredExpression disease BEFREE Furthermore, augmented mRNA levels of IL1A or interleukin-1 receptor accessory protein (IL1RAP) were associated with shortened survival in HNSCC patients. 27738319 2016
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.360 Biomarker disease CTD_human Altogether, blockade of the IL-1 pathway using anakinra overcame erlotinib resistance in HNSCC xenografts and may represent a novel strategy to overcome EGFR inhibitor resistance for treatment of HNSCC patients. 27738319 2016
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.360 AlteredExpression disease BEFREE We studied whether IL-1α expression is a prognostic marker of distant metastasis in patients with head and neck squamous cell carcinoma (HNSCC). 26460957 2015
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.360 AlteredExpression disease BEFREE Human HNSCC tumors showed higher IL1α mRNA levels compared with matched normal tissue, and IL1α was found to be negatively correlated with survival in patients with HNSCC. 25712126 2015
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.360 Biomarker disease BEFREE Analysis of MDC migration and cytokine secretion revealed that HNSCC triggers the production of tumor-promoting and immunosuppressive cytokines IL-1 and IL-10 and results in an increased MDC migration activity. 17465207 2007
Entrez Id: 3552
Gene Symbol: IL1A
IL1A
0.360 AlteredExpression disease BEFREE We studied the expression of IL-1 (Interleukin 1), IL-2, IL-4, IL-10, GM-CSF (granulocyte/macrophage colony stimulating factor), TNF-alpha (tumor necrosis factor alpha) and IFN-gamma (Interferon gamma) in tumor specimens and adjacent mucosa from 12 patients with squamous cell carcinoma of the head and neck (SCCHN) by reverse-transcribed polymerase chain reaction (RT-PCR). 8820364 1996