Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells. 30925916 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE The most common abnormalities downstream from EGFR in HNSCC are in the PI3K pathway, activated via loss of expression of the regulator PTEN, or via PI3K mutation. 30926065 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Here we explore the impact of hypoxia on the behavior of HNSCC and define that the controlling function of phosphatase and tensin homolog (PTEN) over HIF-1α expression and CSC accumulation are de-regulated during hypoxic events. 31560860 2019
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The aim of the present study was to evaluate the prognostic and predictive impact of PTEN, cMET, and p16 expression in recurrent HNSCC. 30478503 2018
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease CLINVAR Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity. 26619011 2016
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE The purpose of this study was to determine whether single nucleotide polymorphisms (SNPs) in AKT1, AKT2, FRAP1, PIK3CA, and PTEN were associated with treatment response and clinical outcome in patients with head and neck squamous cell carcinoma (HNSCC). 24421178 2015
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE We hypothesize that the loss of PTEN expression as well as the subcellular localization could be of interest as a predictive marker of recurrence in HNSCC. 24366426 2014
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease CTD_human The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. 23873848 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Overall, our study highlights the likely clinical relevance of reduced PTEN expression and/or inactivation in HNSCC progression, while the combined Pten deletion with exposure to tobacco carcinogens or their surrogates may provide a unique experimental model system to study novel molecular targeted treatments for HNSCC patients. 23633918 2013
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma. 23082988 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation. 22037217 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE In addition, miR-9 may function as a tumor suppressor in HNSCC through inhibition of cell proliferation and elevation of tumor suppressor PTEN. 22133638 2012
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Mutations in the genes associated with the PI3K/AKT pathway including PI3K, AKT, RAS and PTEN, are infrequently found within head and neck squamous cell carcinoma and more specifically are rarely reported in oral squamous cell carcinoma (OSCC) cases. 21824802 2011
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE To investigate the role of PTEN loss of expression in head and neck squamous cell carcinoma (HNSCC) response to cetuximab, we used siRNA in Cal 27 cells and then evaluated key signaling protein activation (pAKT and pERK 1/2) as well as cell viability and proliferation. 21042725 2010
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE Activation of the PI3K/AKT/mTOR pathway downstream to kinase receptors, such as EGFR, was found in 57-81% of head and neck squamous cell carcinoma (HNSCC), and was eventually associated with a loss of PTEN function. mTOR was shown to modulate cell proliferation, apoptosis, invasion, and angiogenesis. 17912526 2008
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 AlteredExpression disease BEFREE Our results suggest that nAChRs might exert their function through pathways different from PI3-K/Akt/PTEN and that alpha3, alpha5 or alpha7 nAChR subunit expression might not be useful prognostic markers in HNSCC. 17465209 2007
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Dysregulation of the PI 3-K/AKT/PTEN pathway might contribute to early HNSCC tumorigenesis and might constitute a potential clinical target. 15543611 2005
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease CTD_human Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. 11801303 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease UNIPROT Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10. 11801303 2002
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 GeneticVariation disease BEFREE We sequenced the entire coding region of the PTEN/MMAC1 gene in the remaining tumors displaying loss of heterozygosity and found one terminating mutation in a HNSCC sample. 9458098 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease BEFREE Our results suggest that PTEN may play a role in the genesis of some SCCHNs. 9688299 1998
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 Biomarker disease GENOMICS_ENGLAND Multiple hamartoma syndrome (Cowden's disease). 4635800 1972
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 CausalMutation disease CLINVAR
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.800 CausalMutation disease CGI
Entrez Id: 3621
Gene Symbol: ING1
ING1
0.710 GeneticVariation disease UNIPROT Of 34 informative cases of head and neck squamous cell carcinoma, 68% of tumors showed loss of heterozygosity at chromosome 13q33-34, where the ING1 gene is located. 10866301 2000