Source: ALL
Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker disease CTD_human Elevated pulmonary arterial pressure in Zucker diabetic fatty rats. 30689673 2019
Entrez Id: 9332
Gene Symbol: CD163
CD163 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 3684
Gene Symbol: ITGAM
ITGAM 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 958
Gene Symbol: CD40
CD40 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 2215
Gene Symbol: FCGR3B
FCGR3B 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 4360
Gene Symbol: MRC1
MRC1 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker disease CTD_human Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus. 29988851 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 968
Gene Symbol: CD68
CD68 		0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 5770
Gene Symbol: PTPN1
PTPN1 		0.300 Therapeutic disease CTD_human Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis. 28899902 2017
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker disease CTD_human Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models. 24384915 2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker disease CTD_human Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. 25222487 2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR 		0.300 Biomarker disease CTD_human Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. 22949526 2012
Entrez Id: 1831
Gene Symbol: TSC22D3
TSC22D3 		0.300 Biomarker disease CTD_human The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. 22556341 2012
Entrez Id: 2176
Gene Symbol: FANCC
FANCC 		0.300 Biomarker disease CTD_human Fanconi anemia links reactive oxygen species to insulin resistance and obesity. 22482891 2012
Entrez Id: 4160
Gene Symbol: MC4R
MC4R 		0.300 Biomarker disease CTD_human A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding. 23251400 2012
Entrez Id: 2175
Gene Symbol: FANCA
FANCA 		0.300 Biomarker disease CTD_human Fanconi anemia links reactive oxygen species to insulin resistance and obesity. 22482891 2012
Entrez Id: 1281
Gene Symbol: COL3A1
COL3A1 		0.300 Biomarker disease CTD_human Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. 20836762 2010
Entrez Id: 2200
Gene Symbol: FBN1
FBN1 		0.300 Biomarker disease CTD_human Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. 20836762 2010
Entrez Id: 3667
Gene Symbol: IRS1
IRS1 		0.300 Biomarker disease CTD_human Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900 2009
Entrez Id: 3162
Gene Symbol: HMOX1
HMOX1 		0.300 Therapeutic disease CTD_human Heme oxygenase-1 induction remodels adipose tissue and improves insulin sensitivity in obesity-induced diabetic rats. 19171794 2009
Entrez Id: 4846
Gene Symbol: NOS3
NOS3 		0.300 Therapeutic disease CTD_human Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats. 19008412 2009
Entrez Id: 2876
Gene Symbol: GPX1
GPX1 		0.300 Biomarker disease CTD_human Molecular mechanisms for hyperinsulinaemia induced by overproduction of selenium-dependent glutathione peroxidase-1 in mice. 18560803 2008
Entrez Id: 3643
Gene Symbol: INSR
INSR 		0.300 Biomarker disease CTD_human Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. 18411068 2008