×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
0.320
AlteredExpression
disease
BEFREE
The insulin receptor (IR ) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia , due to the metabolic pathway resistance, as obesity diabetes.
30453495
2018
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
0.320
GeneticVariation
disease
BEFREE
The findings on INSR rs2115386 are supportive of the role of insulin resistance, or the compensatory hyperinsulinemia , in the pathogenesis of DR.
27768789
2016
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
0.320
Biomarker
disease
CTD_human
Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome.
18411068
2008
×
Entrez Id:
3643
Gene Symbol:
INSR
INSR
0.320
Biomarker
disease
CTD_human
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction.
10949030
2000
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.300
Biomarker
disease
CTD_human
Elevated pulmonary arterial pressure in Zucker diabetic fatty rats.
30689673
2019
×
Entrez Id:
2215
Gene Symbol:
FCGR3B
FCGR3B
0.300
Biomarker
disease
CTD_human
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
29035695
2018
×
Entrez Id:
958
Gene Symbol:
CD40
CD40
0.300
Biomarker
disease
CTD_human
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
29035695
2018
×
Entrez Id:
3684
Gene Symbol:
ITGAM
ITGAM
0.300
Biomarker
disease
CTD_human
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
29035695
2018
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.300
Biomarker
disease
CTD_human
Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus.
29988851
2018
×
Entrez Id:
6347
Gene Symbol:
CCL2
CCL2
0.300
Biomarker
disease
CTD_human
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
29035695
2018
×
Entrez Id:
4360
Gene Symbol:
MRC1
MRC1
0.300
Biomarker
disease
CTD_human
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
29035695
2018
×
Entrez Id:
7124
Gene Symbol:
TNF
TNF
0.300
Biomarker
disease
CTD_human
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
29035695
2018
×
Entrez Id:
968
Gene Symbol:
CD68
CD68
0.300
Biomarker
disease
CTD_human
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
29035695
2018
×
Entrez Id:
9332
Gene Symbol:
CD163
CD163
0.300
Biomarker
disease
CTD_human
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
29035695
2018
×
Entrez Id:
5770
Gene Symbol:
PTPN1
PTPN1
0.300
Therapeutic
disease
CTD_human
Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis.
28899902
2017
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.300
Biomarker
disease
CTD_human
Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats.
25222487
2014
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.300
Biomarker
disease
CTD_human
Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models.
24384915
2014
×
Entrez Id:
2175
Gene Symbol:
FANCA
FANCA
0.300
Biomarker
disease
CTD_human
Fanconi anemia links reactive oxygen species to insulin resistance and obesity.
22482891
2012
×
Entrez Id:
1831
Gene Symbol:
TSC22D3
TSC22D3
0.300
Biomarker
disease
CTD_human
The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility.
22556341
2012
×
Entrez Id:
2176
Gene Symbol:
FANCC
FANCC
0.300
Biomarker
disease
CTD_human
Fanconi anemia links reactive oxygen species to insulin resistance and obesity.
22482891
2012
×
Entrez Id:
4160
Gene Symbol:
MC4R
MC4R
0.300
Biomarker
disease
CTD_human
A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding.
23251400
2012
×
Entrez Id:
3953
Gene Symbol:
LEPR
LEPR
0.300
Biomarker
disease
CTD_human
Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.
22949526
2012
×
Entrez Id:
1281
Gene Symbol:
COL3A1
COL3A1
0.300
Biomarker
disease
CTD_human
Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions.
20836762
2010
×
Entrez Id:
2200
Gene Symbol:
FBN1
FBN1
0.300
Biomarker
disease
CTD_human
Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions.
20836762
2010
×
Entrez Id:
3667
Gene Symbol:
IRS1
IRS1
0.300
Biomarker
disease
CTD_human
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
19734900
2009