Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.320 AlteredExpression disease BEFREE The insulin receptor (IR) mediates both metabolic and mitogenic effects especially when overexpressed or in clinical conditions with compensatory hyperinsulinemia, due to the metabolic pathway resistance, as obesity diabetes. 30453495 2018
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.320 GeneticVariation disease BEFREE The findings on INSR rs2115386 are supportive of the role of insulin resistance, or the compensatory hyperinsulinemia, in the pathogenesis of DR. 27768789 2016
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.320 Biomarker disease CTD_human Two novel mutations in the insulin binding subunit of the insulin receptor gene without insulin binding impairment in a patient with Rabson-Mendenhall syndrome. 18411068 2008
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.320 Biomarker disease CTD_human Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. 10949030 2000
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.300 Biomarker disease CTD_human Elevated pulmonary arterial pressure in Zucker diabetic fatty rats. 30689673 2019
Entrez Id: 2215
Gene Symbol: FCGR3B
FCGR3B
0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 958
Gene Symbol: CD40
CD40
0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 3684
Gene Symbol: ITGAM
ITGAM
0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.300 Biomarker disease CTD_human Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus. 29988851 2018
Entrez Id: 6347
Gene Symbol: CCL2
CCL2
0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 4360
Gene Symbol: MRC1
MRC1
0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 7124
Gene Symbol: TNF
TNF
0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 968
Gene Symbol: CD68
CD68
0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 9332
Gene Symbol: CD163
CD163
0.300 Biomarker disease CTD_human Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans. 29035695 2018
Entrez Id: 5770
Gene Symbol: PTPN1
PTPN1
0.300 Therapeutic disease CTD_human Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR-/- mouse model of atherosclerosis. 28899902 2017
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.300 Biomarker disease CTD_human Exposure to a northern contaminant mixture (NCM) alters hepatic energy and lipid metabolism exacerbating hepatic steatosis in obese JCR rats. 25222487 2014
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.300 Biomarker disease CTD_human Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models. 24384915 2014
Entrez Id: 2175
Gene Symbol: FANCA
FANCA
0.300 Biomarker disease CTD_human Fanconi anemia links reactive oxygen species to insulin resistance and obesity. 22482891 2012
Entrez Id: 1831
Gene Symbol: TSC22D3
TSC22D3
0.300 Biomarker disease CTD_human The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. 22556341 2012
Entrez Id: 2176
Gene Symbol: FANCC
FANCC
0.300 Biomarker disease CTD_human Fanconi anemia links reactive oxygen species to insulin resistance and obesity. 22482891 2012
Entrez Id: 4160
Gene Symbol: MC4R
MC4R
0.300 Biomarker disease CTD_human A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding. 23251400 2012
Entrez Id: 3953
Gene Symbol: LEPR
LEPR
0.300 Biomarker disease CTD_human Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice. 22949526 2012
Entrez Id: 1281
Gene Symbol: COL3A1
COL3A1
0.300 Biomarker disease CTD_human Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. 20836762 2010
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
0.300 Biomarker disease CTD_human Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions. 20836762 2010
Entrez Id: 3667
Gene Symbol: IRS1
IRS1
0.300 Biomarker disease CTD_human Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900 2009