Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE Selective inhibition of FKBP51 has emerged as possible novel treatment for diseases like major depressive disorder, obesity, chronic pain, and certain cancers. 31800244 2020
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE We investigated the effects of the rs1360780 polymorphism of the hypothalamic-pituitary-axis related gene FKBP5 in combination with early life stress (ELA) on the structure of hippocampal subfields in MDD. 30986730 2019
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE This is the first study to investigate interactions between FKBP5 variants and a range of environmental stressors in adolescents with a clinical diagnosis of MD. 30953930 2019
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE The aim of the present study was to review and conduct a meta-analysis on the results from published studies examining interaction between FKBP5 gene variants and early-life stress and their associations with stress-related disorders such as major depression and PTSD. 28850857 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE There is strong evidence suggesting altered regulation of steroid receptor hormones by chaperones, particularly the 51 kDa FK506-binding protein (FKBP51), may work with environmental factors to increase susceptibility to various psychiatric illnesses including post-traumatic stress disorder (PTSD), major depressive disorder (MDD), and anxiety. 30585227 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE In all participants, lower FKBP5 intron methylation levels were associated with reduced gray matter concentration in the inferior frontal orbital gyrus bilaterally (Wald chi-square=11.93, p<sub>FDR</sub><0.01) and, in MDD, with its bilaterally higher activation during valence recognition (Wald chi-square=5.58, p=0.02). 29182159 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE Our goal was to study the role of FKBP5 genetic variants in HPA axis negative feedback regulation as a possible risk factor for different mental disorders such as MDD and OCD, while controlling for childhood trauma, anxiety and depressive symptoms. 30107269 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE Three samples with major depressive disorder (total=671) were genotyped for 44 SNPs in 8 candidate genes (CACNA1C, CACNB2, ANK3, GRM7, TCF4, ITIH3, SYNE1, FKBP5). 28989100 2018
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE Single nucleotide polymorphisms (SNPs) in the FKBP5 gene are associated with altered hypothalamus-pituitary-adrenal (HPA) axis function, changes in the structure and function of several cognitive brain areas, and increased susceptibility to post-traumatic stress disorder, major depression, bipolar disorder and suicidal events. 28002634 2017
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE Gene-wide significant results were found for dexamethasone suppression (CYP11A1, CYP17A1, POU1F1, AKR1D1), hippocampal volume (CYP17A1, CYP11A1, HSD3B2, PROP1, AVPRA1, SRD5A1), amygdala volume (POMC, CRH, HSD3B2), and lifetime MDD diagnosis (FKBP5 and CRH), all permutation p-values<0.05. 28589964 2017
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE Our findings suggest that the FKBP5 gene and its epigenetic changes could have influence on morphologic changes of several brain regions involved in emotion regulation, and that this process may be associated with the development of MDD. 28198448 2017
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE In contrast, NR3C2, FKBP5 and CRHR1 polymorphisms were not significantly associated with MDD. 27549215 2017
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE The aim of this study was to analyze the expression of 3 genes involved in the regulation of HPA axis: GR, HSP90 and FKBP5, in patients with major depressive disorder (MDD) before antidepressant treatment and after 8 weeks of pharmacotherapy. 29432501 2017
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE A total of 298 major depressive disorder (MDD) inpatients from the multicentred German project and the Zurich Algorithm Project were genotyped for their FKBP5 status. 26645208 2016
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE We tested the relationship between genotype, gene expression and suicidal behavior and major depressive disorder (MDD) in live subjects and postmortem samples for three genes, associated with the hypothalamic-pituitary-adrenal axis, suicidal behavior, and MDD; FK506-binding protein 5 (FKBP5), Spindle and kinetochore-associated protein 2 (SKA2), and Glucocorticoid Receptor (NR3C1). 27030168 2016
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE Future research should also investigate possible gender- and ethnicity-specific differences in the association between FKBP5 and MDD. 27601205 2016
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. 25436518 2015
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease PSYGENET The FK506-binding protein 51 (FKBP51, encoded by the FKBP5 gene) is an established risk factor for stress-related psychiatric disorders such as major depression. 25436518 2015
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease BEFREE Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients. 25355489 2015
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease PSYGENET Therefore, the results suggest that accumulation of the GR in cytoplasm is related to the elevation of FKBP5, adding one more step in understanding altered GR signalling in lymphocytes, and potentially brain tissue, of MDD patients. 25355489 2015
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease PSYGENET We have observed an association between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) and major depressive disorder (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively), but not bipolar disorder. 24856550 2014
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE We have observed an association between five FKBP5 polymorphisms (rs1360780, rs9470080, rs4713916, rs9296158 and rs9394309) and major depressive disorder (p=0.011; p=0.007, p=0.038; p=0.030; p=0.018, respectively), but not bipolar disorder. 24856550 2014
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease PSYGENET In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are associated with DNA methylation and FKBP5 gene expression after psychosocial stress. 25522420 2014
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 GeneticVariation disease BEFREE In the present study, we investigated whether the FKBP5 polymorphism rs1360780 and lifetime history of major depression are associated with DNA methylation and FKBP5 gene expression after psychosocial stress. 25522420 2014
Entrez Id: 2289
Gene Symbol: FKBP5
FKBP5
0.600 Biomarker disease PSYGENET Genetic variations in the co-chaperone FK506-binding protein 51, FKBP5, which modulates the function of glucocorticoid receptors, have been associated with an increased risk for the development of posttraumatic stress disorder, but data regarding its role in MDD are controversial. 23861224 2013