Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. 29467617 2018
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE Disrupted-in-schizophrenia 1 (<i>DISC1</i>) is a strong candidate susceptibility gene for a spectrum of neuropsychiatric diseases including schizophrenia, bipolar disorder and major depression, all of which are thought to result from interactions between gene mutations and environmental risk factors such as influenza, trauma and stress. 30116177 2018
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE A balanced chromosomal translocation disrupting DISC1 (Disrupted in Schizophrenia 1) gene has been linked to psychiatric diseases, such as major depression, bipolar disorder and schizophrenia. 30597994 2018
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 AlteredExpression disease BEFREE In this review, we discuss the expression of DISC1, DBZ, and SGK1 in oligodendrocytes, their roles in the regulation of oligodendrocyte function, possible interactions of DISC1 and DBZ in relation to SZ, and the activation of the SGK1 signaling cascade in relation to MDD. 25705664 2015
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE Recently several potential susceptibility genes for major psychiatric disorders (schizophrenia and major depression) such as disrupted-in-schizophrenia 1(DISC1), dysbindin and pituitary adenylate cyclase-activating polypeptide (PACAP) have been reported. 25595671 2015
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease PSYGENET In this review, we discuss the expression of DISC1, DBZ, and SGK1 in oligodendrocytes, their roles in the regulation of oligodendrocyte function, possible interactions of DISC1 and DBZ in relation to SZ, and the activation of the SGK1 signaling cascade in relation to MDD. 25705664 2015
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease PSYGENET In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions. 24934694 2014
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively). 25043320 2014
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease PSYGENET Evidence of association among rs3738401 (DISC1), rs1615409 and rs766288 (TSNAX) and MDD was found (p=0.004, p=0.0019, and p=0.008, respectively). 25043320 2014
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE Our findings suggest that morphological changes in the hippocampus, ACC, and/or striatum of MDD patients do not represent neurobiological mechanisms underlying the association between DISC1 and MDD. 25012417 2014
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease PSYGENET Disrupted in schizophrenia 1 (DISC1) is a risk factor for a spectrum of neuropsychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder. 25272038 2014
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE In a large Scottish pedigree, disruption of the gene coding for DISC1 clearly segregates with major depression, schizophrenia and related mental conditions. 24934694 2014
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease PSYGENET Disrupted-in-schizophrenia 1 (DISC1) is a promising candidate susceptibility gene for psychiatric disorders, including schizophrenia, bipolar disorder and major depression. 25487992 2014
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE However, subsequent studies have shown association of DISC1 variants with a range of different neurocognitive phenotypes and psychiatric disorders, including bipolar disorder (BPD), and major depression. 23389941 2013
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE The Disrupted in Schizophrenia 1 (DISC1) gene has been associated with the risk of schizophrenia, schizoaffective disorder, bipolar disorder, major depression, autism, and Asperger syndrome in different populations. 21222298 2011
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE Disrupted in schizophrenia 1 (DISC1) is one of the strongest supported risk genes for psychiatric disorders, such as schizophrenia, major depression, bipolar disorder, and autism. 21757008 2011
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE We focused on the overlapping symptoms between CFS and MDD and performed an association study of the functional single-nucleotide polymorphism (SNP) in the DISC1 gene with CFS. 20227423 2010
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). 19255581 2010
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE Pericentrin (PCNT) interacts with disruption-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). 19448849 2009
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE Disrupted in Schizophrenia 1 (DISC1) is currently one of the most interesting candidate genes for major mental illness, having been demonstrated to associate with schizophrenia, bipolar disorder, major depression, autism, and Asperger's syndrome. 19251251 2009
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE The phosphodiesterase 4B (PDE4B) interacts with disrupted-in-schizophrenia 1 (DISC1), which is a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). 18785206 2009
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE Disrupted-in-schizophrenia-1 (DISC1) is one of major susceptibility factors for a wide range of mental illnesses, including schizophrenia, bipolar disorder, major depression and autism spectrum conditions. 18762802 2008
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 GeneticVariation disease BEFREE Recently, PDE4A5 has been shown to bind with disrupted in schizophrenia 1 (DISC1), which has been identified as a risk factor for schizophrenia, bipolar disorder, and major depression. 19018233 2008
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE A possible biological mechanism of MDD might be implicated by these convergent data that Cys704 DISC1 is associated with the lower biological activity on ERK signaling, reduced brain gray matter volume and an increased risk for MDD. 16959794 2006
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
0.400 Biomarker disease BEFREE Since then, genetic analysis has implicated DISC1 in schizophrenia, schizoaffective disorder, bipolar affective disorder, and major depression. 16699061 2006