Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE Thus, the 5-HT1A receptor gene illustrates the convergence of genetic, epigenetic and posttranscriptional mechanisms in gene expression, neurodevelopment and neuroplasticity, and major depression. 30807072 2019
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE <b>Conclusions:</b> The interactions between 5-HT1A and VEGF gene polymorphisms may play a key role in the development of MDD in the Northern Chinese Han population. 31057436 2019
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE Vilazodone, a combined serotonin reuptake inhibitor and 5-HT1A partial agonist, is an approved therapy for the treatment of MDD and which has been further investigated for GAD. 30475091 2019
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE A preliminary association study between serotonin transporter (5-HTTLPR), receptor polymorphisms (5-HTR1A, 5-HTR2A) and depression symptom-clusters in a north Indian population suffering from Major Depressive Disorder (MDD). 31228794 2019
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE We also present clinical data that show promise for identifying biomarkers of 5-HT activity, 5-HT1A regulation and regional changes in brain activity in MDD patients that may provide biomarkers for tailored interventions to overcome or bypass resistance to SSRI treatment. 31114473 2019
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE The 5-HT1A autoreceptor mediates feedback inhibition of serotonin (5-HT) neurons, and is implicated in major depression. 29636529 2018
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE The serotonin receptor 1A and 1B (HTR1A/1B) gene have been suggested to be involved in the pathogenesis of major depressive disorder (MDD) and the antidepressant treatment response. 29275155 2018
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE A Novel Alternative Splicing Mechanism That Enhances Human 5-HT1A Receptor RNA Stability Is Altered in Major Depression. 30093565 2018
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE The common polymorphism rs6295 of the serotonin-1A receptor gene (HTR1A) is affecting the transcriptional regulation of the 5-HT<sub>1A</sub> receptor and has been closely linked to MDD. 28608854 2017
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE The aim of this study is to explore whether the variants in the 5-HT1A and 5-HT2A gene are susceptible to SZ or MDD in the Chinese Han population. 27756686 2016
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE The purpose of this review is to describe the evolution of our current understanding of the serotonin 1A (5-HT1A) receptor and its role in the pathophysiology MDD through the discussion of animal, post-mortem, positron emission tomography (PET), pharmacologic and genetic studies. 26851834 2016
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE This article evaluates the role of 5-HT1A-R genotypes on the profile of cognitive function in patients with major depressive disorder (MDD). 26780922 2016
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE Multiple lines of research have implicated the serotonin 1A (5-HT1A) receptor in major depressive disorder (MDD). 25578798 2015
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE A total of 26 outpatients with treatment-resistant MDD and 27 matched healthy controls underwent magnetic resonance imaging and genotyping for six SNPs in monoaminergic genes [serotonin transporter (SLC6A4), norepinephrine transporter (SLC6A2), serotonin 1A and 2A receptors (HTR1A and HTR2A), catechol-O-methyltransferase (COMT), and brain-derived neurotrophic factor (BDNF)]. 25990886 2015
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders. 24607934 2014
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease PSYGENET Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder. 24911443 2014
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease PSYGENET In MDD, however, the effect of the val66met polymorphism is not detectable, possibly due to a ceiling effect of over-expression of 5-HT(1A) receptors in mood disorders. 24607934 2014
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity. 24180393 2014
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE Somatodendritic 5-hydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone. 23809646 2014
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease PSYGENET Somatodendritic 5-hydroxytryptamine1A (5-HT1A) autoreceptor function in major depression as assessed using the shift in electroencephalographic frequency spectrum with buspirone. 23809646 2014
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease PSYGENET Transcriptional dys-regulation in anxiety and major depression: 5-HT1A gene promoter architecture as a therapeutic opportunity. 24180393 2014
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE Interaction of 5-HTT and HTR1A gene polymorphisms in treatment responses to mirtazapine in patients with major depressive disorder. 24911443 2014
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE Preclinical and imaging/post-mortem studies in humans provide strong support for the involvement of HTR1A and HTR2A genes in MD. 23547754 2013
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 GeneticVariation disease BEFREE The serotonin 1A receptor gene (HTR1A) has been associated with mood disorders (MDs), including major depressive disorder (MDD) and bipolar disorder (BP). 22752684 2013
Entrez Id: 3350
Gene Symbol: HTR1A
HTR1A
0.400 Biomarker disease BEFREE To further explore the genetic components of MDD and utility of 5-HT(1A) imaging as a potential tool for biomarker or treatment response prediction, these findings should be replicated in a larger cohort using the [(11)C]CUMI-101 agonist tracer. 23440462 2013