Gene Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 Biomarker disease BEFREE Moreover, we demonstrate that EBF1-PDGFRB synergizes with loss of IKAROS function in a fully penetrant B-ALL in vivo. 28555080 2018
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 GeneticVariation disease BEFREE In humans, somatic mutations in IKZF1 have been linked to the development of B cell acute lymphoblastic leukemia (ALL) in children and adults. 29889099 2018
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 Biomarker disease BEFREE Reconstitution of PAX5 and IKZF1 in samples from patients with pre-B ALL restored a non-permissive state and induced energy crisis and cell death. 28192788 2017
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 Biomarker disease BEFREE Here we found that activation of STAT5 worked together with defects in signaling components of the precursor to the B cell antigen receptor (pre-BCR), including defects in BLNK, BTK, PKCβ, NF-κB1 and IKAROS, to initiate B-ALL. 28369050 2017
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 GeneticVariation disease BEFREE Thus, performing the present meta-analysis provides valuable information to further elucidate the prognostic value of IKZF1 deletion in adults with ALL. 27815723 2017
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 GeneticVariation disease BEFREE Prognostic impact of IKZF1 deletion in adults with common B-cell acute lymphoblastic leukemia. 27067989 2016
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 GeneticVariation disease BEFREE IKZF1 alterations are highly involved even in adults with B-ALL. 23751147 2013
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 Biomarker disease ORPHANET IKZF1 alterations are highly involved even in adults with B-ALL. 23751147 2013
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 GeneticVariation disease BEFREE IKZF1 gene deletions have been associated with a poor outcome in pediatric precursor B-cell acute lymphoblastic leukemia. 22875627 2013
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 GeneticVariation disease BEFREE The Ikaros (Ikzf1) gene, encoding a transcription regulator, is a major tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL). 19796813 2010
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 Biomarker disease ORPHANET Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia. 19129520 2009
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 Biomarker disease BEFREE Pre-B cell receptor-mediated cell cycle arrest in Ph(+) ALL cells critically depends on IKAROS function, and is reversed by coexpression of the dominant-negative IKAROS splice variant IK6. 19620627 2009
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 Biomarker disease ORPHANET IKZF1 (Ikaros) deletions in BCR-ABL1-positive acute lymphoblastic leukemia are associated with short disease-free survival and high rate of cumulative incidence of relapse: a GIMEMA AL WP report. 19770381 2009
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 Biomarker disease ORPHANET BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. 18408710 2008
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
0.400 AlteredExpression disease BEFREE We examined the expression of Ikaros isoforms in 11 leukemic cell lines and adult acute lymphoblastic leukemia cells from 36 patients with B-precursor acute lymphoblastic leukemia (pre-B ALL) and nine with T-precursor acute lymphoblastic leukemia (pre-T ALL), using reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. 12094252 2002